摘要
采用间接免疫荧光技术检测了22例晚期血吸虫病患者肝脏内γ干扰素(IFN-γ)的分布。发现晚期血吸虫病患者肝内IFN-γ主要分布于汇管区虫卵肉芽肿内、肉芽肿外层和虫卵周围。大量纤维结缔组织增生的汇管区基本无或有很少量的IFN-γ存在.提示IFN-γ可能在血吸虫病的肝脏免疫病理中起重要作用。
The distribution of interferon-Y(INF-Y) in the liver of 22 patients with advanced schistosomiasis japonica was detected with indirect immunofluo-rescence method using monoclonal antibody. It was found that INF-Y was mainly located in egg granulomas, around eggs in the portal area of the liver of patients with advanced schistosomiasis, and in the outlayer of granuloma. The INF-Y around eggs was dispersively distributed. Little or no INF-Y was deposited in some portal areas in which a large amount of fibrotic tissue was proliferated. The results indicate that INF-Y may play an important role in the liver immunopathology of patients with schistosomiasis japonica.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1992年第6期364-366,共3页
Acta Universitatis Medicinae Tongji
关键词
血吸虫病
肝
Γ干扰素
schistosomiasis japonica
liver
interferon-γ
