摘要
目的 :探讨晚期肿瘤患者下呼吸道感染的细菌学分类情况及抗生素耐药性特点。方法 :采用回顾性调查 10 7例晚期肿瘤患者并下呼吸道感染痰菌分离的病原菌并分析其特点 ,药敏试验采用 K-B纸片法。结果 :13 7株病原菌 ,G-杆菌 67株 (48.9% ) ,G+球菌 44株 (3 2 .1% ) ,真菌 2 6株 (19.0 % )。主要致病细菌依次为铜绿假单胞菌 19.7% ,金黄色葡萄球菌 13 .9% ,肺炎克雷伯菌 10 .9%。万古霉素、新霉素、环丙沙星对 G+ 球菌较敏感 ;环丙沙星、阿米卡星、头孢哌酮对 G- 杆菌作用较强 ,其他抗菌药物对各种病原菌均呈现不同程度的耐药。结论 :晚期恶性肿瘤并下呼吸道感染的病原菌多为条件致病菌 ,耐药率高。应加强病原菌培养及药敏监测 。
Objective:To investigate the distribut io n and drug sensitivity of bacteria from advanced cancer patients with lower resp iratory tract infection.Methods:Retrospective study of prem cultures of sputum specimen s in advanced cancer patients with lower respiratory tract infection.Drug sensit ivity was tested by Kirby-Bauer disk sensitivity method.Results:67 of 137 strains were Gram negative bacillin(48 9%),4 4 strains were Gram positive cocci(32 1%) and fungi(19 0%) The predominant pat hogens were Pseudomonas aeruginosa (19 7%),Staphylococcus(13 9%),K lebsiella( 10 9%) Norvancomycin,neomycin and ciprofloxacin were the most active agents ag ainst Gram positive cocci.Ciprofloxacin amikacin and cefperazone were the most a ctive agents against Gram negative bacillin.The others were drug fast against cl inical isolates in defferent degrees. Conclusions:The conditioned pathogenic bacteria were the major p athogens in advanced cancer patients with lower respiratory tract infection and most of them resisted to antibiotics.Sputum culture and drug sensitivity should be seriously considered and reasonble application of antibiotics should be empha sized.
出处
《中国微生态学杂志》
CAS
CSCD
2003年第6期343-344,共2页
Chinese Journal of Microecology
关键词
晚期肿瘤
下呼吸道感染
细菌学分类
抗生素
耐药性
Cancer patients
Infection
Lower respiratory tract
Pathog ens
Resistance drugs
