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胶质瘤耐药机制的研究进展 被引量：1

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摘要 胶质瘤是颅内发生率最高的恶性肿瘤,占中枢神经系统恶性肿瘤的80%[1]。胶质母细胞瘤（glioblastoma,GBM）约占原发性脑肿瘤的16%[2],中位生存期为912个月[3]。目前GBM标准治疗[4]:术后同步放化疗+替莫唑胺（TMZ）辅助化疗。然而GBM 5年存活率仍低于10%[5],中位生存期为1619个月[6]。主要原因是原发耐药胶质瘤较多,即使患者在临床治疗过程中。
作者 孙红军 姜拓之 荔志云
机构地区 兰州军区兰州总医院神经外科
出处 《西北国防医学杂志》 CAS 2016年第6期400-403,共4页 Medical Journal of National Defending Forces in Northwest China
关键词 胶质瘤 耐药机制 分子分型 个体化治疗
分类号 R739.41 [医药卫生—肿瘤]
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参考文献26

  • 1Ahmed Kamal,Manda Sathish,V. Lakshma Nayak,Vunnam Srinivasulu,Botla Kavitha,Yellaiah Tangella,Dinesh Thummuri,Chandrakant Bagul,Nagula Shankaraiah,Narayana Nagesh.??Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability(J)Bioorganic & Medicinal Chemistry . 2015 (17)
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  • 4Ramsay E E,Dilda P J.Glutathione S-conjugates as prodrugs to target drug-resistant tumors. Front Pharmacol . 2014
  • 5Lin BC,Su LH,Weng SC, et al.DNA Topoisomerase Ⅱ Is Involved in Regulationof Cyst Wall Protein Genes and Differentiation in Giardia lamblia.. PLoS Negl Trop . 2013
  • 6MichelDemeule,DanielShedid,édithBeaulieu,Rolando F.Del Maestro,AlbertMoghrabi,Pierre B.Ghosn,RobertMoumdjian,FranceBerthelet,RichardBéliveau.??Expression of multidrug‐resistance P‐glycoprotein (MDR1) in human brain tumors(J)Int. J. Cancer . 2001 (1)
  • 7Quintavalle C,Mangani D,Roscigno G,et al.miR-221/222target the DNA methyltransferase MGMT in glioma cells. PLo S One . 2013
  • 8Maher EA,Furnari FB,Bachoo RM,et al.Malignant glioma: genetics and biology of a grave matter. Genes and Development . 2001
  • 9Kreth Simone,Thon Niklas,Eigenbrod Sabina,Lutz Juergen,Ledderose Carola,Egensperger Rupert,Tonn Joerg C,Kretzschmar Hans A,Hinske Ludwig C,Kreth Friedrich W.O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. PloS one . 2011
  • 10Agarwal Sagar,Manchanda Pooja,Vogelbaum Michael A,Ohlfest John R,Elmquist William F.Function of the blood-brain barrier and restriction of drug delivery to invasive glioma cells: findings in an orthotopic rat xenograft model of glioma. Drug metabolism and disposition: the biological fate of chemicals . 2012

二级参考文献30

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西北国防医学杂志
2016年 第6期

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