摘要
目的 观察大剂量甲基强的松龙冲击疗法(methyperdnisolone pulse therapy,MPPT)治疗放射性脑病(radiation encephalopathy,REP)的疗效。方法 将25例REP患者随机分为实验组(大剂量MPPT)与对照组(常规治疗),疗程3个月,观察治疗前后临床评分、免疫功能、头颅磁共振(MRI)、日常生活能力(ADL)等指标变化。结果 实验组总有效率(85.72％)明显高于对照组(36.36％),头颅MRI显示病灶体积及IgG、C4较对照组均有明显改善。结论 大剂量MPPT对治疗REP具有良好效果。
Objective To study the therapeutic effect of methyperdnisolone pulse therapy(MPPT) on radiation encephalopathy(REP). Methods To compare the result of MPPT and regular therapy in relevant indexes, including clinical sign, serum IgG, IgM, IgA, C3, C4 and lesion volumn in MRI, ADL scores. Results The effect of MPPT was more efficient than regular therapy in improving the clinical symptom, lesion volumn and immune function ( IgG, C4). Conclusions High-dose MPPT can be proposed to the effective therapy in REP.
出处
《中国神经免疫学和神经病学杂志》
CAS
2003年第4期251-253,共3页
Chinese Journal of Neuroimmunology and Neurology
