摘要
本文采用现代色谱分离手段从嗜低温真菌Pseudogymnoascus pannorum的大米发酵产物中分离得到8个化合物,采用现代波谱技术鉴定其结构,分别为:L-pyroglutamyl-L-phenylalanine(1)、(R)-N-acetylphenylalanine(2)、(R)-Nacetyltryptophan (3)、methyl 2-hydroxy-4-(3-hydroxy-5-methylphenoxy)-6-methylbenzoate (4)、2-hydroxy-4-(2-hydroxy-3-methoxy-5-methylphenoxyl)-6-methylbenzoate(5)、vanillic acid(6)、1,3,5-三甲氧基苯(7)和亚油酸(8)。其中化合物1和2为首次从天然界分离得到,化合物3～8为首次从假裸囊菌属真菌中分离得到。化合物1～8对人肝癌细胞Hep G-2和人乳腺癌细胞MCF-7未显示细胞毒作用。
Eight compounds were isolated from the rice fermentation of a psychrophilic fungus Pseudogymnoascus pannorum.Their structures were identified as L-pyroglutamyl-L-phenylalanine(1),(R)-N-acetylphenylalanine(2),(R)-N-acetyltryptophan(3),methyl 2-hydroxy-4-(3-hydroxy-5-methylphenoxy)-6-methylbenzoate(4),2-hydroxy-4-(2-hydroxy-3-methoxy-5-methylphenoxyl)-6-methylbenzoate(5),vanillic acid(6),1,3,5-trimethoxybenzene(7),and linoleic acid(8).Among them,compounds 1 and 2 were first isolated from natural resources,while others were isolated from the genus of Pseudogymnoascus for the first time.Compounds 1-8 did not show cytotoxicity against human hepatoma Hep G-2 or human breast cancer MCF-7 cells.
作者
郭永智
魏茜
高洁
刘冰语
张涛
华会明
胡友财
GUO Yong-zhi;WEI Qian;GAO Jie;LIU Bing-yu;ZHANG Tao;HUA Hui-ming;HU You-cai(School of Traditional Chinese Medicine,Shenyang Pharmaceutical University,Shenyang 110016,China;Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2019年第3期446-449,505,共5页
Natural Product Research and Development
基金
国家自然科学基金(81522043)
作者简介
通信作者:胡友财,Tel:86-10-61271883;E-mail:huyoucai@imm.ac.cn
