摘要
目的 :探讨不同剂量奥扎格雷治疗急性脑梗死的临床药物剂量效应关系。方法 :2 86例急性脑梗死病人分成 3组。在常规治疗(吡拉西坦 ,维生素E ,胞磷胆碱 ,血栓通等 )基础上 ,治疗Ⅰ组 :男性5 4例 ,女性 42例 ,年龄 (5 4±s 8)a,给奥扎格雷 80mg ,iv ,gtt,bid ,1 0d;治疗Ⅱ组 :男性 5 7例 ,女性 3 8例 ,年龄 (5 4±8)a,给奥扎格雷 40mg ,iv,gtt,bid,1 0d ;对照组 :男性 5 5例 ,女性 40例 ,年龄 (5 4± 7)a,仅用常规治疗。结果 :治疗Ⅰ组总有效率 97% ,治疗Ⅱ组总有效率 96% ,对照组总有效率 81 % ,3组间疗效比较经Ridit分析 ,治疗Ⅰ组、治疗Ⅱ组与对照组临床疗效比较均有非常明显差异 (P <0 .0 1 ) ,而治疗Ⅰ组与治疗Ⅱ组比较 ,差异不显著 (P >0 .0 5 ) ,治疗组除少数病人出现皮下瘀血、血尿外 ,未出现严重并发症。结论 :小剂量奥扎格雷治疗急性脑梗死亦有肯定疗效。
AIM: To explore the clinical dose-effect relation of different doses ozagrel i n treating acute cerebral infarction. METHODS: Two hundred and eighty-six patients with acute cerebral infraction w ere divided into 3 groups. Based on conventional therapy (piracetam, vitamin E, citicoline, Xueshuantong, etc) treatment I group (M 54,F 42;age (54±s 8 )a) was treated with ozagrel 80 mg iv, gtt, bid, for 10 d and treatment Ⅱ gro up (M 57,F 38;age(54±8)a) was treated with ozagrel 40 mg iv, gtt, bid, for 10 d. Control group (M 55,F 40;age(54±7)a) was with conventional therapy only. RESULTS: The total effective rates were 97 %, 96 % in treatment Ⅰ,Ⅱ group a nd 81 % in control group. Curative effect contrast among 3 groups was analyzed by R idit method. The difference between treatment groups (Ⅰ,Ⅱ) and control group was obvious (P<0.01), but the difference between treatment I group and treat ment Ⅱ group was not obvious (P>0.05). There were no serious adverse reacti ons except for ecchymosis and hematuria in a few patients during ozagrel treatme nt period. CONCLUSION: Small dose ozagrel has sure curative effect in treating acute cer ebral infarction.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2003年第10期609-611,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
大脑梗死
剂量效应关系
药物
药物疗法
奥扎格雷
cerebral infaraction
does-response relationship, drug
drug therapy
ozagrel .
