摘要
目的:研究玉米皮膳食纤维对反式脂肪酸所致小鼠胰岛素抵抗的影响。方法:采用反式脂肪酸饲料诱导建立小鼠高脂血症模型,分别给予低、中、高3种剂量3种玉米皮膳食纤维(水溶性膳食纤维(soluble dietary fiber,SDF)、水不溶性膳食纤维(insoluble dietary fiber,IDF)和m(SDF):m(IDF)=1∶3)。结果:反式脂肪酸的摄入导致小鼠血糖水平、血清胰岛素水平和胰岛素抵抗指数显著增加(P<0.01),胰岛素敏感指数、胰岛β细胞功能和总超氧化物歧化酶显著降低(P<0.01)。玉米皮膳食纤维干预能够降低小鼠血糖水平和胰岛素抵抗指数,提高胰岛素敏感指数和胰岛β细胞功能,且高剂量m(SDF)∶m(IDF)=1∶3的玉米皮膳食纤维干预组以上指标与反式脂肪酸组对比,差异均非常显著(P<0.01),效果最好。结论:反式脂肪酸能够导致小鼠胰岛素抵抗,玉米皮膳食纤维干预能够改善小鼠的胰岛素抵抗状况,且高剂量m(SDF)∶m(IDF)=1∶3效果最好。
Objective: This study aimed to evaluate the effects of dietary fiber from corn husk on trans fatty acids-induced insulin resistance in mice. Methods: The mouse model of hyperlipidemia was established by feeding with a diet with transfatty acids. Different groups of mice were given water-soluble dietary fiber, water-insoluble dietary fiber alone or their combination with an SDF to IDF of ratio of 1:3(m/m) at low, moderate and high doses. Results: The intake of trans fatty acids significantly elevated fasting blood glucose, fasting serum insulin, homeostasis model assessment-insulin resistance significantly(P < 0.01), and reduced insulin sensitivity index, islet β-cell function and total superoxide dismutase(T-SOD) significantly(P < 0.01). Dietary fiber from corn husk significantly reduced fasting blood glucose and insulin resistance(P < 0.01), and significantly elevated insulin sensitivity index and islet β-cell function(P < 0.01). Compared with those in the hyperlipidemia model group, these parameters in mice fed with high dose of SDF:IDF changed significantly(P < 0.01). Conclusions: Trans fatty acids can lead to insulin resistance in mice. Intervention with corn husk dietary fiber can improve the symptoms, and the best effect is achieved by the intake of high dose of SDF:IDF.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2014年第13期218-222,共5页
Food Science
基金
国家高技术研究发展计划(863计划)项目(2010AA023003-01)
