摘要
目的:研究青刺尖茶汤对便秘模型小鼠的润肠通便作用。方法:将雄性昆明小鼠随机分为空白组、模型组、阳性组和低、中、高3个剂量的给药组。给药组分别经口给予低、中、高剂量(1、2、6 g/(kg·d))的青刺尖茶汤;空白组和模型组给予0.3 mL/20 g的蒸馏水;阳性组给予0.9 g/(kg·d)的麻仁丸。连续灌胃7 d后,观察各组小鼠的首次排黑便时间、5 h内排便粒数,测定粪便含水量和小肠墨汁推进率。结果:3个剂量组与模型组和阳性组比较,各测定指标都有显著性差异;青刺尖茶汤能明显缩短小鼠首次排黑便时间,增加小鼠5 h内排便数量、粪便含水量和小肠推进率。结论:青刺尖茶汤有明显的润肠通便功效。
Objective: To explore the laxative effect of Prinsepia utilis tea(PUT) infusion on constipated mice. Methods: Male Kunming mice were randomly divided into control group, model control group, positive control group and low, medium- and high-dose treatment groups which were administered with PUT infusion at 1, 2 and 6 g/(kg·d)) for 7 days, respectively. The mice from both the blank control and model control groups were administered with distilled water at a volume of 0.3 mL/20 g for 7 days, while those from the positive control group were administered with Marenwan at a dose of 0.9 g/(kg·d) for 7 days. After the administration period, the time of the first black feces excretion and the number of feces granules within 5 h were recorded. Fecal water content and ink propelling rates were measured. Results: All the tested parameters differed significantly between each dose of PUT infusion and either the model group or the positive control group. PUT could markedly shorten the time of the first black feces excretion, increase the number of feces granules within 5 h. In addition, water content of mouse feces and ink propelling rates also revealed a significant increase. Conclusion: Prinsepia utilis tea has an obvious laxative effect.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2014年第11期265-268,共4页
Food Science
关键词
青刺尖茶
通便
小鼠
便秘
Prinsepia utilis tea
defecation
mouse
constipation
