摘要
目的:基于非肌松条件行小儿全麻气管插管操作,探究此时复合使用瑞芬太尼与丙泊酚标准剂量的ED_(50)值与ED_(95)值。方法:择取2014年12月到2016年12月期间于本院基于非肌松条件行全麻气管插管操作的30例患儿,在复合使用标准剂量丙泊酚进行麻醉的前提下,以2.5μg/kg为初始剂量使用瑞芬太尼,随后按照1.1倍的标准不断追加2次用药,即2.3μg/kg、2.7μg/kg。对比瑞芬太尼用量为2.5μg/kg、2.3μg/kg、2.7μg/kg时患儿在插管前1分钟、插管时、插管后5分钟这三个时间点的指标——呼吸频率与平均动脉压,还有心血管阳性反应发生率,分析达到满意气管插管条件时瑞芬太尼的ED_(50)值与ED_(95)值。结果:瑞芬太尼用量为2.5mg/kg时患儿呼吸频率、平均动脉压在各时间点均低于其他两种用量;就心血管阳性反应发生率而言,用量为2.7mg/kg为93.33%(28/30),2.5μg/kg时为53.33%(16/30),2.3μg/kg时为23.33%(7/30);ED_(50)值与ED_(95)值分别为2.3μg/kg、2.7μg/kg,置信区间分别为(2.2～2.4)μg/kg、(2.6～3.4)μg/kg。结论:若要取得满意气管插管效果,ED_(50)值与ED_(95)值应为2.3μg/kg[(2.2～2.4)μg/kg]、2.7μg/kg[2.6～3.4)μg/kg]。
Objective:To study the ED50 value and ED95 value of remifentanil and propofol standard dose in combination with non-muscle relaxation.Methods:A total of 30 children who underwent total anesthesia tracheal intubation were enrolled in the hospital from December 2014 to December 2016.Under the condition of combined use of standard dose of propofol for anesthesia,2.5μg/Kg,followed by 1.1 in the standard,2.3μg/kg,2.7μg/kg.When the dose was 2.5μg/kg,2.3μg/kg,2.7μg/kg,compare the HR and MAP.Nalysis of satisfactory tracheal intubation conditions when the remifentanil ED50 value and ED95 value.Results:The mean arterial pressure was lower than that of the other two doses at the time of 2.5mg/kg.The incidence of cardiovascular positive reaction was 93.33%（28/30）,53.33%（2.5/30）at2.5μg/kg and 23.33%（7/30）at 2.3μg/kg;ED50 and ED95 were 2.3μg/kg,2.7μg/kg（2.2～2.4）μg/kg,（2.6～3.4）μg/kg,respectively.Conclusion:If you want to achieve satisfactory effect of tracheal intubation,ED50 value should be 2.3 g/kg[and ED95（2.2～2.4）g/kg],2.7 g/kg[2.6～3.4)g/kg].
出处
《中国妇幼健康研究》
2017年第S3期21-21,共1页
Chinese Journal of Woman and Child Health Research
关键词
瑞芬太尼
丙泊酚
小儿非肌松条件
全麻
气管插管
ED50/ED95值
remifentanil
propofol
pediatric non-muscle relaxation condition
general anesthesia
tracheal intubation
ED50/ED95 value
