摘要
目的:探讨用硫唑嘌呤治疗克罗恩病的临床效果。方法 :对2008年6月~2013年6月期间我院收治的55例克罗恩病患者的临床资料进行回顾性研究。我们将这55例患者随机分为观察组(28例)和对照组(27例)。我们为对照组患者使用艾迪莎进行治疗,为观察组患者使用硫唑嘌呤进行治疗。治疗结束后,比较两组患者的治疗效果。结果 :治疗结束后,观察组患者的临床缓解率、不良反应的发生率均明显好于对照组患者,二者相比差异具有显著性(P<0.05)。观察组患者的CDAI评分明显低于对照组患者,二者相比差异具有显著性(P<0.05)。观察组患者各项生化指标的水平均好于对照组患者,二者相比差异具有显著性(P<0.05)。结论 :用硫唑嘌呤治疗克罗恩病的临床效果好,安全性高。此治疗方法值得在临床上推广应用。
Objective: on crohn's disease clinical alleviate its long-term clinical studies. Selection methods: in June 2008 to June 2013 were 55 cases of crohn disease as the research object, by the patients in our hospital ethics committee approval and informed consent under the check is divided into the control group(27 cases) and group(28 cases) and control group treated by etiasa, team with azathioprine treatment, analysis before and after treatment of crohn's disease activity index changes, and monitoring of adverse reactions. Results: the team through the use of azathioprine treatment, patients with clinical response rate was 71.4%, the adverse reaction rate was 28.6%, crohn's disease activity index(138.5-5.5), and the control group were 55.6%, 44.4%,(159.0-8.0) compared with group difference between statistically significant(P < 0.05). Biochemical indicators, statistically significant difference between the two group patients group(P < 0.05). Conclusion: azathioprine for crohn's disease clinical treatment can achieve the ideal effect, but need to carry out the right amount, long range and clinical individualized treatment in order to reduce the incidence of adverse reactions.
关键词
克罗恩病
硫唑嘌呤
临床缓解
Crohn's disease
Azathioprine
clinical remission
