摘要
观察老年大鼠下丘脑视上核腹侧大细胞神经元和弓状核神经元的超微结构,结果显示:老年大鼠视上核腹侧血管加压素(VP)神经元的胞体较成年鼠大,胞质结构比较致密,内含许多核糖体颗粒,粗面内质网分散成小泡状,神经分泌颗粒增多,溶酶体、线粒体、高尔基氏复合体数量都较多.而弓状核内的暗细胞和亮细胞的核糖体减少,高尔基氏复合体和线粒体都变化,还有少数神经元固缩,细胞质内胞器明显减少,呈现变性现象.结果提示:老年期下丘脑视上核VP神经元机能增强;而弓状核内两种细胞都显示机能减弱的征象.老年时下丘脑各核团神经元的这种不协调性变化,可能是动物衰老的一种重要表现.
Magnocellular neurons in the supraoptic nucleus and neurons in the arcuate nucleus of aged rat's hypothalamus were examined with electron microscope.In comparison with adult rats,the neurons in ventral part of the supraoptic nucleus of aged rats were larger,and three cytoplasm was denser,containing many ribosomes,alveolar rough-endoplasmic reticula,and number-increased neurosecretory particles and organellae such as lysosomes,mitochondrie and Golgi's complex,Whereas in the dark cells and the light cells of the arcuate nucleus,the number of ribosomes and the size of Golgi's complex and mitochondria decreased.Moreover a few of the arcuate nucleus neurons were shrank,and contained much less organellar,showing degeneration changes.The results suggest that in the aged rats,the functions of neurons increase in the supraoptic nucleus,but decrease in the arcuate nucleus,the inconsistent changes probably bearing importance in aging animals,
出处
《解剖学杂志》
CAS
CSCD
北大核心
1992年第6期431-433,共3页
Chinese Journal of Anatomy
关键词
鼠
视上核
弓状核
超微结构
老年
aged rat
supraoptic nucleus
arcuate nucleus
ultrastructure
