摘要
目的 观察全身炎症反应综合征 (SIRS)患者血清前白蛋白 (PAB)和透明质酸 (HA)水平变化并探讨其临床意义。方法 符合SIRS诊断 4 8例 ,清晨空腹抽肘静脉血 5mL ,采用免疫散射比浊法检测PAB含量 ,放射免疫法检测HA含量 ,并选择健康体检者 4 1例作为对照组。结果 SIRS患者血浆PAB含量比对照组显著下降 (P <0 0 1) ;而血浆HA水平与对照组比较明显升高 (P <0 0 1) ;氧合指数与对照组比较无显著差异 (P >0 0 5 )。器官功能不全组血浆PAB含量比器官功能正常组更低 (P <0 0 5 ) ;而血浆HA水平高于器官功能正常组 (P <0 0 1)。结论 SIRS患者血浆PAB、HA水平变化可作为判断病情和监测MODS发生的敏感指标 ,并提示在治疗疾病过程中护肝治疗是重要一环。
Objective To observe the changes of serum prealbumin(PAB)and hyaluronic acid(HA)levels in patients with systemic inflammatory response syndrome (SIRS)and to study their clinical values.Methods Forty-eight patients according with SIRS diagnosis were in the trial group, and 41 healthy people were in the control group.Five milliliter blood was drawn from elbow vein of each patient respectively in the morning.PAB were detected by immune scattery radio nephelometry, while HA were detected by radio immune assay.Result Serum PAB level in patients with SIRS was lower than that in control group(P<0.01),while HA level was higher in the trial group than in control group (P<0.01).Oxygen combine index was no more different between the trial group and control group (P>0.05).Serum PAB was more less in the organ malfunction group than that in the normal organ function group(P<0.05),but HA was much higher in the organ malfunction group than that in the normal organ function group (P<0.01).Conclusions The changes of both serum PAB and HA levels in patients with SIRS could be considered as sensitive indexes to predict the risk of the multiple organ dysfunction syndrome (MODS).It suggested that it should be important to protect liver in treatment.
出处
《中国急救医学》
CAS
CSCD
北大核心
2003年第7期474-475,共2页
Chinese Journal of Critical Care Medicine
关键词
全身炎症反应综合征
前白蛋白
透明质酸
Systemic inflammatory response syndrome
Prealbumin
Hyaluronic acid
