摘要
研究了系列 PEG-b-PBT嵌段共聚物在 p H=7.4磷酸盐缓冲溶液中和 37℃条件下的体外降解行为 .同时观察了水解降解过程中系列共聚物溶胀率、失重、特性粘度、结晶度和表面形态等方面的变化 .实验结果表明 ,嵌段共聚物的组成直接影响其水解降解性能 ,共聚物的溶胀率和失重率随聚醚组分含量而增大 ;通过调节共聚物的组分比可以达到调节降解速率的目的 .此外研究还表明 ,共聚物最初的降解主要发生在软段和硬段相联的酯键上 .
The degradation behavior of the copolymers are investigated by immersing the copolymer film into PBS(pH=7.4) at 37 ℃ in a shaking bath .The influence of the copolymer composition on physical properties, including the swelling ratio, the weight loss, the inherent viscosity, the surface morphology of polymer films, as well as the degree of crystallization is discussed. The experimental results reveal that the degradable profiles can be controlled by changing the copolymer composition.It is shown that the intial degradation of copolymer comes from the cleavage of the ester bonds between hydrophilic PEG and hydrophobic PBT.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2003年第6期1122-1125,共4页
Chemical Journal of Chinese Universities
基金
国家"八六三"计划 (批准号 :2 0 0 1A A2 16 0 77)资助
