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急性髓系白血病患者抗凝骨髓及血清HGF和TGFβ1水平检测的临床意义 被引量:4

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摘要 骨髓基质细胞能表达和分泌肝细胞生长因子(Hepatocyte growth factor,HGF),造血干/袒细胞存在其相应受体(c-met受体),它们的相互作用调控着细胞的增埴、分化、粘附及生存[1,2].转化生长因子β1(Thansforming growth factor β1,TGF-β1)是TGF家族中的重要成员之一,是一种细胞增埴负调控因子,具有抑制间质细胞分泌HGF及抑制HGF细胞有丝分裂的促进作用[3].
出处 《临床血液学杂志》 CAS 2003年第3期136-138,共3页 Journal of Clinical Hematology
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参考文献3

  • 1Pons E, Uphoff C C, Drexler H U. Expression of hepatocyte growh factor and its receptor c-met in leukemialymphoma cell line. Leuk Res, 1998, 22:797--804.
  • 2Nakamura S, Gohda E, Matsuo Y, et al. Significant amount of hepatocyte growth factor detected in blood and bone marrow plasma of leukemia patients. Br J Haematol, 1994, 87:640--642.
  • 3Masuhara M. Expression of hepatocyte growgh factor and transforming growth factor bl mRNA in P acnes and lipopolysaccharide-treated rats. J Gastroenterol,1995, 30:48--48.

同被引文献33

  • 1张之南 沈悌.血液病诊断及疗效标准·第二版[M].北京:科学出版社,1999.245.
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  • 3Von dem Borne A,Folman C,Van den Oudenrijin S,et al.The potential role of thrombopoietin in idiopathic thrombocytopenic purpura.Blood Rev,2002;16 (1):57.
  • 4Robin J,A Filshie.Cytokines in haemopoietic progenitor mobilization for peripheral Blood stem cell transplantation.Currrent Pharmaceutical Design,2002;8 (5):379.
  • 5Ling E,Robinson DS.Transforming growth factor-beta 1:its antiin flammatory and pro-fibrotic effects.Clin Exp Allergy,2002;32(2):175.
  • 6Athanasia Mouzaki,Maria Theodoropoulou,Ioannis Gianakopoulos.Expression patterns of Th1 and Th2 cytokine genes in childhood idiopathic thrombocytopenic purpura(ITP) at presentation and their modulation by intravenous immunoglobulin G (IVIg) treatment:their role in prognosis.Blood,2002;100 (5):1774.
  • 7Kingasa S,Abe S,Tachibana M.OVerexpression of transforming growth factor beta 1 in scirrhous carcinoma of the stomach correlates with decreased survival.J Oncology,1998;55(6):582.
  • 8Gohda E,Takebe G,Sotani T,et al.Induction of hepatocyte growth factor/scatter factor by nterfrongamma in human leukemia[J].J Cell Physiol,2004,174(1):107-114.
  • 9Hussong JM,Rodgers GM,Shami PJ.Evidence of increased angiogenesis in patients with acute myeloid leukemia[J].Blood,2005,96(10):3356-3357.
  • 10Fiedler W,Graeven U,Erguns S,et al.Vascular endothelial growth factor,a possible paracrine growth factor in human acute myloid leukemia[J].Blood,2002,89(6):1870-1875.

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