摘要
目的设计合成eudistominU及其 6位甲氧基取代的衍生物并测试其抗肿瘤活性。方法以吲哚 3 甲醛和色胺或 5 甲氧基色胺为原料先缩合 ,再通过Pictet Spengler反应环合得到四氢 β 咔啉 ,然后用DDQ脱氢芳构化得到目标化合物。结果合成了eudistominU及其 6位甲氧基取代的衍生物 ,利用核磁共振、质谱进行了结构确认。结论合成了海洋生物碱eudistominU及其 6位甲氧基取代的衍生物 。
Aim To synthesize euditstomin U and its 6 OCH 3 analogue as an antitumor agent.Methods Form tryptamine and indole 3 aldehyde as starting materials,thorugh condensation,Pictee Spengler cyclization and dehydrogenation,the alkaloids and its 6 OCH 3 analogue were prepared.Results The structures of the synthesized compounds were determined by 1 H NMR and MS.The antitumor activity in vitro was tested.Conclusion Eudistomin U and its 6 OCH 3 were synthesized.The results show that they all possess antitumor activities against mouse P388 strain.
出处
《中国药物化学杂志》
CAS
CSCD
2003年第2期67-69,共3页
Chinese Journal of Medicinal Chemistry
基金
国家自然科学基金资助项目(2 98-72 0 2 9)
国际合作项目(20 0 10 14 0 417)
