摘要
目的:基于大量临床研究数据,采取多种统计学方法,筛查随访5个月、10个月特发性肺间质纤维化急性加重期(AE-IPF)的危险因素。方法:采取回顾性分析研究,对既往336例特发性肺间质纤维化稳定期患者及随访5个月、10个月的临床研究数据进行归纳,采用频数分布、相关数据分析以及Logistic回归分析等方法,分析AEIPF的危险因素。结果:筛查5个月AE-IPF的危险因素有:1年前急性加重次数、急性加重持续时间、呼吸困难评分(mMRC)、肺功能分级、ESQ-IPF日常生活与能力、干咳等;筛查10个月AE-IPF发生的危险因素有:1年前急性加重次数、急性加重持续时间、呼吸困难评分(mMRC)、肺功能分级、CAT问卷评分、IPF-PRO临床症状、ESQ-IPF日常生活与能力、干咳等。结论:影响AE-IPF发生的危险指标包括疾病相关情况(1年前急性加重次数、急性加重持续时间、mMRC)、临床相关检查(FEV1及肺功能分级)、生存质量量表(CAT、ESQ-IPF日常生活与能力)、临床症状(刺激性干咳、呼吸困难等),并进行针对性的干预,减少AE-IPF的发生。
Objective:Based on a large number of clinical research data,a variety of statistical methods were adopted.The risk factors of acute exacerbation of idiopathic pulmonary interstitial fibrosis were screened and followed up for 5 and 10 months.Methods:Retrospective analysis was used to summarize the clinical data of 336 patients with idiopathic pulmonary interstitial fibrosis in stable stage who were followed up for 5 months and 10 months.The risk factors of AE-IPF were analyzed by frequency distribution,related data analysis and Logistic regression analysis.Results:The risk factors of AE-IPF in 5 months were:the number of acute exacerbations,duration of acute exacerbations,dyspnea score(mMRC),pulmonary function classification,ESQ-IPF daily life and ability,dry cough,etc.The risk factors of AE-IPF in 10 months were:the number of acute exacerbations,duration of acute exacerbations,dyspnea score(mMRC),pulmonary function classification,CA,etc.T-questionnaire scores,IPF-PRO clinical symptoms,ESQ-IPF daily life and ability,dry cough and so on.Conclusion:Risk indicators affecting the occurrence of AE-IPF include disease-related conditions(number of acute exacerbations a year ago,duration of acute exacerbations,mMRC),clinical related examinations(FEV1 and pulmonary function classification),quality of life scale(CAT,ESQ-IPF daily life and ability),clinical symptoms(irritating dry cough,dyspnea,etc.),and targeted interventions to reduce the occurrence of AE-IPF.
作者
邓岳潼
吕晓东
庞立健
刘创
于睿智
郑钰
牟虹霖
DENG Yuetong;LYU Xiaodong;PANG Lijian;LIU Chuang;YU Ruizhi;ZHENG Yu;MU Honglin(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2019年第7期93-96,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81373579)
国家自然科学基金青年基金项目(81403290)
国家“十二五”中医药管理局中医络病重点学科建设项目(T0302)
辽宁省高等学校科学研究一般项目基础研究(L2014369)
作者简介
邓岳潼(1993-),女(满族),辽宁本溪人,硕士研究生,研究方向:中医药防治肺纤维化的基础和临床研究;通讯作者:吕晓东(1966-),女,辽宁沈阳人,教授,博士研究生导师,博士,研究方向:中医药治疗肺系疾病的基础和临床研究。
