摘要
探讨α-干扰素治疗慢性丙型肝炎患者对其外周血T淋巴细胞亚群及可溶性白细胞介素2受体变化的作用。用国产α-干扰素治疗18例慢丙肝患者,分别检测其治疗前后外周血T淋巴细胞亚群及可溶性白细胞介素2受体。检测方法分别用流式细胞仪和双抗夹心ELISA法。α-干扰素抗病毒治疗后,随病毒复制指标阴转,血清可溶性白细胞介素2受体水平下降,细胞免疫功能改善。免疫反应参与丙型肝炎发病,观测T淋巴细胞亚群及可溶性白细胞介素2受体的变化,对判断干扰素治疗丙型肝炎的疗效有十分重要的意义。
To study the effect of interferon (α - INF) on patients with chronic hepatitis C peripheral - blood T lymphocytes sub -group and soluble interleukin 2 receptors ( sIL - 2R) . T lymphocytes subgroup and soluble interleukin 2 receptor were detected respectively before and after the treatment of α - INF in 18 cases with chronic hepatitis C. After the therapy of α - INF the level of reproduce of virus and the sIL- 2R were desended, and the function of cellular immunity was improved. The study showed that it is important to predict the efficacy of α- INF.
出处
《临床肝胆病杂志》
CAS
北大核心
2003年第2期92-93,共2页
Journal of Clinical Hepatology
