摘要
目的探讨男性住院病人尿路感染病原菌的分布、构成比及其耐药性,为临床医生合理应用抗菌药物提供依据。方法对2168例泌尿外科住院男性病人的病历资料,包括年龄、疾病、血常规、尿常规、尿培养及药敏试验结果进行回顾性分析。结果 2168例病人尿培养阳性402例,尿培养阳性率为18. 54%。病原菌主要为大肠埃希菌(37. 06%)、粪肠球菌(19. 9%)、铜绿假单胞菌(7. 96%)、肺炎克雷伯菌(7. 46%)、白色念珠菌(5. 22%)。大肠埃希菌最敏感的抗菌药物为替加环、美洛培南、亚胺培南;耐药率较高的抗菌药物为氨苄西林、哌拉西林、头孢唑啉。粪肠球菌最敏感药物为磷霉素、替考拉宁、替加环素;耐药性较高的药物为红霉素。结论男性病人发生尿路感染的致病菌主要为大肠埃希菌、粪肠球菌。病人尿培养及药敏结果出来前可经验性地给予抗菌药物,再根据尿培养及药敏结果调整用药。
Objective To investigate the antimicrobial resistance pattern of main pathogens in male inpatients with urinary tract infection in department of urology,provide clinical evidences for clinicians to prescribe the appropriate antibiotics and prevent antibiotic resistance. Methods Analyze the medical records of 2168 cases of male inpatients retrospectively,including age,disease,blood routine examination,urine examination,urine culture and antimicrobial susceptibility test. Results A total of 2168 cases of patients were collected,of which 402 cases with positive urine culture,the urine culture positive rate was 18. 54%. The main pathogens of urinary tract infection are Escherichia coli(37. 06%),Enterococcus faecalis(19. 9%),Pseudomonas aeruginosa(7. 96%),Klebsiella pneumoniae(7. 46%),Candida albicans(5. 22%). For Escherichia coli most susceptibility was to Tigecycline,meropenem,imipenem and the most resistance to Ampicillin,piperacillin,cefazolin. For Enterococcus faecalis most susceptibility was to Fosfomycin,teicoplanin,Tigecycline and the most resistance to erythromycin. Conclusion The pathogens of urinary tract infection are mainly Escherichia coli and Enterococcus faecalis. In clinical work,we can give empirical antibiotic therapy based on the distribution of pathogens in this region or the hospital before we have the results of urine culture,and adjust antibiotic therapy according to the results of urine culture.
作者
陆金金
刘海浪
朱伟
王少刚
杨为民
LU Jinjin;LIU Hailang;ZHU Wei(Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《临床外科杂志》
2019年第2期113-116,共4页
Journal of Clinical Surgery
关键词
泌尿外科
男性
尿路感染
病原菌
耐药
urinary surgery
male
urinary tract infection
pathogens
antimicrobial resistance
作者简介
通信作者:杨为民,Email:wmyang@tjh.tjmu.edu.cn
