摘要
液体活检技术是通过对癌症患者体液(特别是血液和尿液)中的特异性肿瘤标志物如循环肿瘤细胞(CTCs)、循环肿瘤DNA等进行检测并分析,其对肿瘤的临床分期、远处转移、预后判断、耐药性的形成机制以及个体化治疗指导都具有深远意义。前列腺癌早期诊断较为困难,而且部分病例恶性程度高,易复发和转移。近几年来,该技术已经应用在前列腺癌诊治中并积累了许多非常有价值的临床数据和经验。本文对液体活检技术在前列腺癌中的研究现状及面临的挑战作一综述。
Liquid biopsy is a popular technology to detect and analyze specific tumor biomarkers(such as circulating tumor cells,circulating tumor DNA,etc.)in the body fluids(especially blood and urine)of cancer patients.It plays a key role in clinical tumor staging,metastasis,prognosis,drug resistance research and individualized treatment.It is well known that early diagnosis of prostate cancer is a little difficult,and part of patients show high malignancy and incidence of recurrence and metastasis.In recent years,this technology has been used in the diagnosis and treatment of prostate cancer and accumulated a lot of very valuable clinical data and experience.This review summarized recent literature and briefly discussed the current status and challenges of liquid biopsy in prostate cancer.
作者
林智谦
王世博
梁英
田俊强
LIN Zhiqian;WANG Shibo;LIANG Ying;TIAN Junqiang(Department of Urology,Second Hospital of Lanzhou University,Institute of Urology of Second Hospital of Lanzhou University,Key Laboratory for Urological Diseases of Gansu Province,Gansu Nephro Urological Clinical Center,Lanzhou,730030,China)
出处
《临床泌尿外科杂志》
2019年第2期154-156,160,共4页
Journal of Clinical Urology
基金
甘肃省卫生行业科研计划项目(编号GWGL2013-30)
兰州大学第二医院2015年度第二批院内博士科研基(编号ynbskyjj2015-2-7)
关键词
液体活检技术
循环肿瘤细胞
循环肿瘤DNA
前列腺癌
liquid biopsy technology
circulating tumor cells
circulating tumor DNA
prostatic cancer
作者简介
通信作者:田俊强,E-mail:tjq007263@sina.com
