摘要
目的 对比观察两种放疗方式治疗鼻咽癌的局部控制率及急性反应和晚期损伤。方法 60例NO-2患者随机分为两组,一组采用标准超分割(HFR)方式放疗,总量DT 76.8 Gy;另一组采用前后程加速超分割(AHFR)方式放疗,总量DT72～75 Gy。结果 (1)两组的5年总生存率和5年无病生存率分别为69.84％、65.86％和62.86％、55.35％。两组的局部控制率均为93.33％。(2)AHFR组与HFR组的急性黏膜反应程度相似,AHRF组略高于HFR组。晚期反应两组无明显差异。(3)放疗结束时局部肿瘤的近期消退率AHFR组低于HFR组。半年时两者CT消退率相同。结论 两种放疗方式无明显差异,标准超分割放疗方式更简便易行。
Objective To compare and evaluate the tumor local control rate,the normal tissue acute radiation reaction and the radiation damage of two radiation methods in nasopharyngeal carcinoma ( NPC) . Methods 60 patients of NPC in NO-2 were randomized into two groups. The patients in the first group were treated with standard hyperfractionated radiotherapy (HFR), the total dose Dr 76.8 Gy. The patients in the second group were treated with early and late course accelerated hyperfractionated radiotherapy (AHFR), the total dose Dr 72 ~ 75 Gy. Results (1) The overall 5-year survival rate was 69.84% for AHFR,and 65.86% for HFR.The 5-year disease-free survival rate was 62.86 % for AHFR, and 55.35 % for HFR, respectively. The local control rate of both groups were 93. 33%. (2)The rates of acute reaction of mucosa and late radiation complications were similar in both groups. (3) The initial tumor response rate at the complication of radiation therapy in the AHFR group was lower than that of in the HFR group.The tumor responses rates evaluated by CT for both groups at half a year after RT were the same. Conclusion The standard hyperfractionated radiotherapy is more convenient than accelerated hyperfractionated radiotherapy.
出处
《中国肿瘤临床与康复》
2003年第1期44-46,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
四川省卫生厅资助项目(940059)
关键词
非常规分割
放疗
治疗
鼻咽癌
疗效分析
Nasopharyngeal neoplasms/radiotherapy
Hyperfractionated radiotherapy
