摘要
绵羊肺腺瘤病 ( OPA)是由外源性的 D型和 B型绵羊肺腺瘤反转录病毒 ( JSRV)引起的肺脏肿瘤性疾病 ,该病毒主要在肺肿瘤上皮细胞内高水平表达 ,病毒基因组内 L TR的活化和病毒囊膜蛋白的表达是引起体外细胞转化癌变的主要因素 ,其致瘤的可能机制是通过激活磷酯酰肌醇 3 -激酶 ( PI-3 K)和蛋白酶 K( AKT)信号通路来启动细胞内抑制细胞凋亡和刺激细胞增生的信号转导系统 ,从而引起细胞增生癌变。该病与人的细支气管 -肺泡癌 ( BAC)极相似 ,通过对 OPA的研究 ,不仅为早期诊断及预防该病提出新方法 ,而且为揭示 BAC的分子发病机制及探索其基因治疗提供新思路。
Ovine pulmonary adenomatosis(OPA) is an exogenous type D and B retrovirusinduced spontaneous lung tumor of sheep. The etiologic agent of OPA,Jaagsiekte sheep retrovirus(JSRV),is expressed highly in the neoplasm epithelial cells of the lung. Activation of The long terminal repeat(LTR) of JSRV genome and expression of the JSRV envelope protein is sufficient to induce cell transformation in vitro, possibly via the activation of the phosphatidylinositol 3kinase(PI3K)/Aktsignaling pathway,then it can initiates a cellsignaling pathway that appears to inhibit apoptosis and to stimulate proliferation .OPA strongly resembles human bronchioloalveolar carcinoma(BAC).Studying OPA can provide new methods of diagnosis and preventing,it also offer new insights into gene therapy of BAC.
出处
《动物医学进展》
CSCD
2003年第1期19-22,共4页
Progress In Veterinary Medicine
基金
内蒙古自治区重点领域研究资助项目(ZL9903)
