摘要
目的 为了更有效治疗缺氧缺血性脑损伤 (HIBD) ,减少永久性伤残。方法 将 60例中重度HIBD的新生儿分成早期干预组和对照组 ,经新生儿期治疗后 ,对干预组治疗加用运动、认知、语言和社会交往能力的训练 ,时间为 2年。用发育商 (DQ)和临床资料对治疗效果作评估。结果 比较两组生后 3、6、12、18、2 4个月龄时的发育商 (DQ) ,干预组DQ值明显高于对照组 (P <0 .0 5 ,P <0 .0 1)。干预组总的预后不良率为 5 % ,预后不良率明显低于对照组 (P <0 .0 5 )。结论 婴儿期脑的代偿和可塑能力最强。早期干预可促进脑的迅速发育 ,使神经细胞之间的连接通路广泛而完善 ,代偿已受损的神经细胞的功能。早期干预是治疗HIBD行之有效的方法 。
Objective For more effective treatment and reduction of permanent disability of hypoxic ischemic brain damage (HIBD) caused of newborn asphyxia.Methods Sixty cases of mild and serious newborns with HIBD were divided into the early intervention treatment group and control group. After HIBD early treatment, for the intervention group, the training of motion, cognition, language and social intercourse were given for two years. The development quotient (DQ) and clinical date were used to evaluate treatment effect.Results Compared with the score of DQ that was followed up for 3 , 6, 12, 18 and 24 moths, the DQ of the intervention group was obviously higher than that of the control group (P<0.05,P0.01). The percentage of unfavorable prognosis of the intervention group was only 5 %, obviously lower than that of the control group (P<0.05).Conclusions The ability of compensation and plasticity of the brain is best in the early infant stage. Early intervention can promote brain development and the connective passageways of never cells. It is valuable for the improvement of the patient′s prognosis.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2003年第2期114-115,共2页
Journal of Applied Clinical Pediatrics
基金
成都市卫生局青年基金 (项目编号 :2 0 0 0 1 4 )
关键词
缺氧缺血性脑损伤
早期
干预治疗
hypoxic ischemic brain damage
early
intervention treatment
