摘要
目的 调查分析阴沟肠杆菌对临床常用抗生素的耐药情况。方法 对四川大学华西医院 2 0 0 1年 4月～ 2 0 0 2年 11月从临床分离的 10 1株阴沟肠杆菌采用琼脂平皿对倍稀释法测定 12种抗生素的最低抑菌浓度 (MIC) ,分析耐药情况。结果 阴沟肠杆菌对氨苄西林、头孢呋辛的耐药率高达 99 0 0 %、87 13 % ,对第三代头孢菌素、氟喹诺酮类的耐药率高于 5 0 % ,对头孢哌酮 /舒巴坦、头孢吡肟、阿米卡星的耐药率低于40 % ,亚胺培南对 90 %以上的分离株具有抗菌活性。氟喹诺酮类药物的交叉耐药严重。结论 阴沟肠杆菌耐药水平高 ,多重耐药现象普遍存在。
Objective To study the resistance of clinical isolates of Enterobacter cloacae to antimicrobial agents . Methods A total of 101 strains of E.cloacae were isolated from clinical specimens in West China Hospital of Sichuan University from April 2001 to November 2002. The MICs of twelve antimicrobial agents against the strains were detected by two fold agar dilution method. Results The resistant proportions of E.cloacae to ampicillin and cefuroxime were as high as 99 00% and 87 13% respectively. The resistant rates to third generations cephalosporins and fluoroquinolone were more than 50%. Cefoperazone/sulbactam, cefepime and amikacin were able to inhibit about 60%～70% of isolates. Imipenem was active against more than 90% of the isolates. Cross resistance among fluoroquinolone was significant. Conclusion The situations of antibiotic resistance of E.cloacae was serious,and multidrug resistance was prevalent among clinical isolates of E.cloacae . Imipenem retained greatest activities against E.cloacae collected.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2003年第3期147-149,共3页
Chinese Journal of Antibiotics
关键词
阴沟肠杆菌
耐药性
最低抑菌浓度
抗生素
Enterobacter cloacae
Drug resistance
Minimal inhibitory concentration
