摘要
目的比较昆仙胶囊(KUN XIAN)与来氟米特(Leflunomide, LEF)单药治疗类风湿关节炎(rheumatiod arthritis, RA)患者的临床疗效。方法选取RA患者80例,随机分为KUAN XIAN组(50例)和LEF组(30例)。分别于第0、4、12周比较两组的临床指标,包括红细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein, CRP)、类风湿因子(rheumatoid factor, RF)、抗环瓜氨酸抗体(anti-cyclic citrullinated peptide antibody, CCP);同时监测疾病活动度,包括28个关节疾病活动度评分(disease activityscore28,DAS28)、疼痛视觉模拟评分(visualanaloguescore,VAS)及健康评估问卷(healthassessmentquestionnaire, HAQ)。结果 KUN XIAN组在治疗4周后,ESR、CRP、 DAS28、VAS及HAQ评分均较治疗前明显下降,而LEF组则在治疗12周后有显著下降。且在治疗12周后KUN XIAN组ESR、CRP及DAS28水平均明显低于LEF组,而两组的VAS及HAQ评分无显著差异。在治疗12周时,两组的RF及CCP水平均较治疗前显著下降,但两组之间无差异。结论 KUN XIAN治疗RA疗效优于LEF,且起效快。
Objective To compare the clinical efficacy of KUN XIAN with Leflunomide(LEF) in the treatment of rheumatoid arthritis(RA) patients. Methods Eighty patients with RA were randomly divided into KUN XIAN group(50)and LEF group(30). The clinical symptoms, erythrocyte sedimentation rate(ESR), C-reactive protein(CRP), rheumatoid factor(RF), anti-cyclic citrullinated peptide antibody(CCP), disease activity score 28(DAS28), visual analogue score(VAS)and health assessment questionnaire(HAQ) scores of the two groups were determined at the 0, 4 th and 12 th week respectively. Results The values of ESR, CRP, DAS28, VAS and HAQ score were decreased in KUN XIAN group 4 weeks after treatment, and also decreased in LEF group 12 weeks after treatment. The levels of ESR, CRP and DAS28 were decreased more obviously in KUN XIAN group than in LEF group. Furthermore, the values of RF and CCP in both groups were decreased significantly. Conclusion KUN XIAN is superior and faster for the treatment of RA compared to LEF.
作者
刘艳梅
雷易萌
张贝
夏丽萍
鲁静
沈晖
LIU Yan-mei;LEI Yi-meng;ZHANG Bei;XIA Li-ping;LU Jing;SHEN Hui(Department of Rheumatology,the First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China)
出处
《解剖科学进展》
2019年第1期17-20,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金(81373219)
作者简介
通讯作者:沈晖.
