摘要
增生性瘢痕是伤口局部上皮化以后组织继续增生的病理改变 ,是临床上一种较常见的病理性瘢痕。其形成系因创伤愈合过程中成纤维细胞合成与分解代谢紊乱 ,导致细胞外基质合成增多和过度沉积 ,其中胶原为其主要成分。近年的研究表明 ,细胞因子在瘢痕过度形成与重塑中起重要作用。肿瘤坏死因子 (TNF α)主要由激活的单核细胞产生 ,对成纤维细胞胶原合成与分解代谢发挥着重要作用[1] 。作者就近年来TNF
As a kind of familiar pathological scars in clinical practice, hypertrophic scar is the pathological change of tissue hyperplasia after wound healed up.Its formation is due to the fibroblasts function disorderly,which results in excessive production and deposit of the extracellular matrix macromolecules.Among these,collagen is the main member.It has been proved recently that cytokines apparently play an important role in the formation and remodeling of collagenous connective tissues. Tumor necrosis factor α, mainly secreted by macrophages,has great effects on the anabolism and catabolism of fibroblasts.In this review, we summarized the advances in the relationship between TNFα and fibroblasts in hypertrophic scars.
出处
《医学研究生学报》
CAS
2003年第1期41-43,共3页
Journal of Medical Postgraduates
