摘要
人离体血淋巴细胞在G_0、G_1、S和G_2期分别给予41℃1h加热、50 mGy小剂量照射或50 mGy和41℃1h加热联合作用,培养至48 h再给1.5GyX射线照射。结果表明三种预先处理的染色单体畸变率均明显低于单纯1.5Gy组,说明加热和小剂量X射线一样,可诱导细胞对电离辐射的抗性。但50 mGy和41℃ 1h加热联合作用的适应性反应未见累加作用,因此认为低剂量辐射和加热所诱导的适应性反应的机制可能是一致的,即通过热休克蛋白而产生保护作用。
Human lymphocytes pre-treated by heat (41℃ 1h), low dose ir-radiation (50 mGy), or both low dose radiation and heat together, bccame less susce-ptible to chromatid damage induced by subsequent high dose of X-rays. Either heator low dose X-rays could significantly reduced the yield of chromatid aberrations,but the magnitude of adaptive response was not' enhanced when combined treatmentwith low dose radiation and heat were used. The results jmplied that the mechanismof adaptive response induced by low dose X-rays was as same as the mechanism ofadaptive response induced by hyperthermia, which may be related with some protec-tive proteins.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1992年第4期232-235,共4页
Journal of Radiation Research and Radiation Processing
关键词
加热
电离辐射
适应性反应
抗性
Hyperthermia
Radiation
Chromatid aberration
Adaptive response
Heat shock protein
