摘要
2～ 3min的脑缺血对随后的严重脑缺血具有明显保护作用 ,即脑缺血耐受。目前发现蛋白合成、不同类型的离子通道的变化以及胶质细胞的支持参与了脑缺血耐受。研究缺血耐受机制能够为进一步研究脑损伤与保护机制提供新的视角。
A 2 3 min preconditioning can significantly protect against neuronal damage following subsequent lethal brain ischemia (ischemic tolerance). It has been shown that protein synthesis, changes in different type of ion channels and support of glia cells are involved in brain ischemic tolerance. Investigation on mechanisms of ischemic tolerance will provide new insight into mechanisms of neuronal damage and protection.
基金
国家自然科学基金 (3 9970 2 65
3 0 12 5 0 13 )
军队杰出人才基金 (0 1J0 0 9)
广东省团队项目 990 3 95 )资助
