摘要
目的探讨创伤性骨折患者血清高密度脂蛋白(HDL-C)水平与深静脉血栓形成的相关性。方法对2012年4月至2014年12月1 054例创伤性骨折患者进行回顾性研究。按超声筛查结果,分为深静脉血栓组188例,对照组866例,采用单因素和多因素logistic回归分析HDL-C水平与深静脉血栓形成的关系。结果深静脉血栓组的血清HDL-C水平低于对照组,HDL-C水平与深静脉血栓形成相关。HDL-C水平降低、年龄增大、制动时间增加、筛查前未用抗凝药时间增加、输血均是创伤性骨折患者深静脉血栓形成的危险因素;骨折部位不同,形成深静脉血栓的风险不同。深静脉血栓组和对照组中,手术患者较未行手术患者血清HDL-C水平降低。结论创伤性骨折患者血清HDL-C水平与深静脉血栓形成独立相关。
Objective To explore the association of plasma high density lipoprotein-cholesterol(HDL-C)and deep vein thrombosis(DVT)in traumatic fracture patients.Methods We performed a retrospective study in 1 054 traumatic fracture patients admitted between April 2012 and December 2014.188 cases were divided into DVT and others(n=866)into control group based on ultrasound results.The relationship between HDL-C and DVT was determined by univariate and multivariate logistic regression analyses.Results Compared with control group,patients in DVT group had significantly lower HDL-C level,and low level of plasma HDL-C was associated with the occurrence of DVT.Deceased HDL-C,inceased age,inceased immobilization,inceasd anticoagulant-free days,fracture sites,and blood transfusion were risk factors for the occurrence of DVT in traumatic fracture patients.Patients with surgery had significantly lower level of HDL-C in both groups compared with patients without surgery respectively.Conclusion Low level of plasma HDL-C was independently associated with the occurrence of DVT in traumatic fracture patients.
作者
许彬彬
苟泽辉
周莉
李志
陈宇
薛欣盛
李惠萍
XU Bin-bin;GOU Ze-hui;ZHOU Li;LI Zhi;CHEN Yu;XUE Xin-sheng;LI Hui-ping(Department of Intensive Care Unit,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Ultrasonography,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Intensive Care Unit,Cheng Du Shang Jin Nan Fu Hospital,Chengdu 611730,China;Department of Orthopedics,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2019年第2期248-251,共4页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(No.81100189)资助
关键词
高密度脂蛋白
深静脉血栓
骨折
High density lipoprotein
Deep vein thrombosis
Fracture
作者简介
通信作者:李惠萍,E-mail:huipingli2154@hotmail.com
