摘要
Chemistry(Huaxue Tongbao),2019,82(10):899~810 Using pregnenlone as a raw material,the titled compounds were designed and synthesized by esterification on 3-hydroxyl and structural modification on 20-carbonyl.Their antiproliferative activities were evaluated by MTT method in vitro.The results showed that compounds 2d and 3d display distinct antiproliferative activity against A549 with IC50 of 7.9μmol/L and 10.3μmol/L,which were not toxic to HEK-293T cells.
出处
《化学通报》
CAS
CSCD
北大核心
2019年第10期865-866,共2页
Chemistry
