摘要
目的研究肺间质纤维化伴随肺气肿关键危险因素。方法选取2015年1月至2017年12月我院收治50例肺间质纤维化伴随肺气肿病例纳入研究,另选同期50例单纯肺间质纤维化病例纳入对照组,对比2组基本资料、高分辨率CT(HRCT)检测结果、肺功能、静息状态下PaO_2。结果单因素分析中,两组慢性肾脏疾病以及反流性食管炎发生情况、吸烟量对比差异有统计学意义(P<0.05);多因素分析显示,肺间质纤维化伴随肺气肿独立危险因素主要为反流性食管炎与吸烟量(P<0.05);两组HRCT检测结果、肺活量占预计值比率、静息PaO_2对比无统计学意义(P>0.05),研究组FEV1/FVC、DLCO占预计值比率明显小于对照组,且肺总量占预计值比率明显高于对照组(P<0.05)。结论肺间质纤维化伴随肺气肿关键危险因素为长期吸烟、反流性食管炎、肺功能降低等。
Objective To investigate the key risk factor of pulmonary interstitial fibrosis complicated with emphysema.Methods 50 cases with pulmonary interstitial fibrosis complicated with emphysema in our hospital from January 2015 to December 2017 were selected as the observation group,another 50 cases with pulmonary interstitial fibrosis were selected as the control group,general data,HRCT examination results,lung functions and resting PaO2 of the two groups were compared.Results The single factor analysis showed that,there was statistic significance in the occurrence of CRD and reflux esophagitis,smoking amount between the two groups(P<0.05),multiple-factor analysis showed that,independent risk factors of pulmonary interstitial fibrosis complicated with emphysema were reflux esophagitis and smoking amount(P<0.05);there was no statistic significance in the HRCT examination results,the proportion of vital capacity in the predicated value,resting PaO2 between the two groups(P>0.05),the proportion of FEV1/FVC,DLCO in the predicated value in the observation group was significantly less than that in the control group,and the proportion of TLC in the predicated value was significantly higher than that in the control group(P<0.05).Conclusion The key risk factors of pulmonary interstitial fibrosis complicated with emphysema are long term smoking,reflux esophagitis,declining lung function and so on.
作者
尹正海
邹永祎
张帆
Yin Zhenghai;Zou Yongyi;Zhang Fan(Respiratory Medicine,The Second People′s Hospital of Nanyang City,Nanyang 473012,China)
出处
《哈尔滨医药》
2019年第1期19-21,共3页
Harbin Medical Journal
关键词
肺间质纤维化
肺气肿
危险因素
Pulmonary interstitial fibrosis
Emphysema
Risk factors
