摘要
本文使用Southern杂交技术研究了33例胃癌及癌旁组织中c-Ha-ras、K-ras、N-ras癌基因的扩增、重排和缺失。结果显示:25.8％(8/33)病例有c-Ha-ras基因的扩增、重排和缺失;3.8％(1/26)病例有K-ras基因的扩增;N-ras基因无上述改变。
The amplification,rearrangement and deletion of c-Ha-ras,K-ras and N-ras were studied in 33 cases of gastric cancerous and juxtacancerous tissues.It was found that the amplification rearangement,and deletion of c-Ha-ras were shown in 25.8% (8/33) of cases and the ampli-cation of K-ras in 3.8% (1/26).No such changes was found for N-ras.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第6期514-518,共5页
Journal of Third Military Medical University
关键词
胃肿瘤
染色体缺失
致癌基因
stomach neoplasms
ras genes
gene amplification
recombination
genetic
chromosome deletion
