摘要
目的 :探讨慢性心力衰竭 (心衰 )患者血清E选择素的变化及福辛普利 (fosinopril)对其影响。方法 :采用双抗体夹心酶联免疫吸附测定法检测 40例慢性心衰患者及 2 0例对照组血清E选择素水平。并将慢性心衰患者分为常规治疗组 (19例 )和福辛普利组 (2 1例 ) ,共观察 3周。结果 :①慢性心衰患者血清E选择素水平显著高于对照组 ,有非常显著性差异 (P <0 0 1)。②常规治疗组和福辛普利组患者经治疗后较治疗前血清E选择素水平和心脏结构均无明显变化 ,但福辛普利组患者经治疗后较治疗前心率明显下降 ,左心室射血分数 (LVEF)明显增高 ,均有显著性差异 (P均 <0 0 5 )。结论 :慢性心衰患者存在血清E选择素水平增高 ,但血清E选择素水平与左心室收缩功能和心脏结构无关。福辛普利治疗可改善心功能 。
Objective: E seclectin serum in 40 patients with chronic heart failure(CHF) and 20 healthy controls was examined by enzyme linked immunosorbent assay Methods: Patients with CHF were randomized to receive routine therapy( n =19) or fosinopril in addition to routine therapy( n =21) for 3 weeks,Their E seleatin levels were evaluated before and after treatment Results: ①The E selectin levels of both CHF groups were higher than those of the control group( p <0 01) ② After treatment no changes of E selectin were found,but in fosinopril group patients had lowered heart rates and increased lefe ventricular ejection fraction Conclusions: Elevated E seleectin levels are present in patients with CHF Fosinopril treatment can improve the left ventricular function,but does not have effects on the E selectin levels of patients with CHF
出处
《中国循环杂志》
CSCD
北大核心
2002年第6期445-447,共3页
Chinese Circulation Journal
