摘要
目的 对比分析甲氧西林敏感金黄色葡萄球菌(MSSA)与肺炎链球菌致社区获得性肺炎(CAP)患者的临床特征和预后。方法 采用前瞻性观察性研究方法,收集2019年2月—2023年1月住院治疗的CAP患者870例,根据致病的病原菌将患者分为MSSA致CAP组(n=51)和肺炎链球菌致CAP组(n=819),对比分析两组患者的临床特点和预后。结果 MSSA致CAP组患者的发热率(62.75%)低于肺炎链球菌致CAP组患者(79.49%);相较于肺炎链球菌,MSSA致CAP患者住院时间长(OR=2.016,P=0.016)、入住ICU率高(OR=3.024,P<0.001)、ICU住院时间长(OR=1.829,P=0.004)、应用机械通气率高(OR=2.243,P=0.002)、入院30 d内死亡率高(OR=2.623,P<0.001)、发病后1年死亡率高(OR=2.779,P=0.033)。结论 MSSA致CAP患者的临床症状相对轻微,但预后差于肺炎链球菌致CAP患者。
Objective To compare and analyze the clinical characteristics and outcomes of community-acquired pneumonia(CAP)caused by methicillin-sensitive Staphylococcus aureus(MSSA)and CAP caused by Streptococcus pneumoniae.Methods A prospective observational study was conducted on 870 patients with CAP diagnosis who were hospitalized during the period from February 2019 to January 2023.The patients were assigned to MSSA or S.pneumoniae group according to the primary pathogen of CAP.The clinical characteristics and outcomes of patients were compared between groups.Results Overall,51 patients with MSSA CAP and 819 patients with S.pneumoniae CAP were included in this study.Fever was reported in 62.75%(32/51)of patients with MSSA-CAP and 79.49%(651/819)of patients with S.pneumoniae CAP.Compared to S.pneumoniae,MSSA was associated with longer hospital stay(OR=2.016,P=0.016),longer ICU stay(OR=1.829,P=0.004),more ICU admission(OR=3.024,P<0.001),more mechanical ventilation(OR=2.243,P=0.002),higher mortality within 30 days of admission(OR=2.623,P<0.001),and higher mortality within 1 year after onset(OR=2.779,P=0.033).Conclusions The clinical symptoms of patients with MSSA CAP are relatively mild,but the outcome is worse than the patients with S.pneumoniae CAP.
作者
陈璐
尚鑫
CHEN Lu;SHANG Xin(Department of Respiratory and Critical Care Medicine,Nanyang First People’s Hospital,Nanyang,473000,China)
出处
《中国感染与化疗杂志》
北大核心
2025年第5期505-510,共6页
Chinese Journal of Infection and Chemotherapy
关键词
甲氧西林敏感金黄色葡萄球菌
肺炎链球菌
社区获得性肺炎
methicillin-sensitive Staphylococcus aureus
Streptococcus pneumoniae
community-acquired pneumonia
作者简介
第一作者:陈璐(1993-),女,医学学士,主治医师,主要从事呼吸系统急危重症患者救治工作。;通信作者:陈璐,E-mail:c15237766137@126.com。
