摘要
目的探讨绝经后女性宫颈高危型人乳头状瘤病毒(HR-HPV)感染情况,并分析其危险因素。方法选取2022年1月至2024年12月在兰州市城关区妇幼保健院进行HR-HPV筛查的5645例绝经后女性,均采用HR-HPV核酸检测试剂盒进行检测,分析绝经后女性宫颈HR-HPV感染情况,采用单因素与多因素logistic回归分析绝经后女性宫颈HR-HPV的危险因素。结果5645例中,宫颈HR-HPV感染789例(13.98%)。感染组年龄较非感染组更大,吸烟史、性伴侣≥2人、有自身免疫性疾病、阴道乳酸杆菌异常比例更高(P<0.05);多因素logistic回归分析结果显示,吸烟史(OR=2.428)、性伴侣≥2人(OR=2.595)、有自身免疫性疾病(OR=3.029)、阴道乳酸杆菌异常(OR=3.822)是影响绝经后女性宫颈HR-HPV感染的独立危险因素(P<0.05)。结论绝经后女性宫颈HR-HPV感染与吸烟史、性伴侣人数、自身免疫性疾病、阴道乳酸杆菌有关,临床需进行针对性干预。
Objective To explore the cervical high-risk human papilloma virus(HR-HPV)infection in postmenopausal women and analyze its risk factors.Methods A total of 5645 postmenopausal women who underwent HRHPV screening in Lanzhou Chengguan District Maternal and Child Health Hospital from January 2022 to December 2024 were selected.All of them were tested by HR-HPV nucleic acid detection kit to analyze the cervical HR-HPV infection in postmenopausal women.Univariate and multivariate logistic regression analysis were used to analyze the risk factors of cervical HR-HPV in postmenopausal women.Results Among the 5645 cases,789 cases(13.98%)were infected with cervical HR-HPV.Compared with the non-infection group,the infection group was older,and had a higher proportion of smoking history,≥2 sexual partners,autoimmune diseases,and abnormal vaginal lactobacillus(P<0.05).Multivariate logistic regression analysis showed that,smoking history(OR=2.428),more than 2 sexual partners(OR=2.595),autoimmune diseases(OR=3.029),abnormal vaginal lactobacillus(OR=3.822)were independent risk factors for cervical HR-HPV infection in postmenopausal women(P<0.05).Conclusion The cervical HR-HPV infection in postmenopausal women is related to smoking history,the number of sexual partners,autoimmune diseases,and vaginal lactobacillus.Targeted intervention is needed in c linical practice.
作者
王晶
WANG Jing(Department of Gynecology,Lanzhou Chengguan District Maternal and Child Health Hospital,Gansu Province,Lanzhou 730030,China)
出处
《妇儿健康导刊》
2025年第17期33-36,54,共5页
Journal of Women and Children's Health Guide
