摘要
目的探讨甘油三酯-葡萄糖指数(triglyceride-glucose index,TyG)、血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)、全身免疫炎症指数(systemic immune-inflammation index,SII)及血肌酐(serum creatinine,SCr)与高脂血症性急性胰腺炎(hyperlipidemic acute pancreatitis,HLAP)疾病严重程度的相关性。方法选取湖州市第一人民医院2020年1月至2024年12月收治的156例HLAP患者作为研究对象,根据病情严重程度分为轻症组(n=89)和中重症组(n=67)。采用Logistic回归分析筛选出独立危险因素,采用Spearman相关性检验分析TyG、AIP、SCr与HLAP严重程度的相关性,采用受试者操作特征曲线(receiver operating characteristic,ROC曲线)评价TyG、AIP、SCr对HLAP的预测价值。结果中重症组患者的TyG、AIP、SII、SCr水平显著高于轻症组,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,TyG、AIP、SCr是中重症HLAP的独立危险因素(P<0.05),而SII不是独立危险因素。HLAP严重程度与入院早期TyG、AIP、SCr水平呈正相关。ROC曲线结果表明,TyG相较SCr、AIP更具有诊断价值。联合指标SCr+AIP、SCr+TyG的预测价值优于单一指标,SCr+TyG的预测价值最高。结论早期TyG、AIP、SCr可作为预测HLAP患者疾病严重程度的有效指标,联合检测可提高预测准确性。
Objective To investigate the correlation between the triglyceride-glucose index(TyG),atherogenic index of plasma(AIP),systemic immune-inflammation index(SII),serum creatinine(SCr)and the severity of hyperlipidemic acute pancreatitis(HLAP).Methods A total of 156 HLAP patients admitted to Huzhou First People’s Hospital from January 2020 to December 2024 were enrolled as subjects.They were divided into mild group(n=89)and moderately-severe/severe group(n=67)based on disease severity.Logistic regression analysis was used to identify independent risk factors.Spearman correlation analysis was used to examine the correlation between TyG,AIP,SCr,and HLAP severity.The predictive value of TyG,AIP,and SCr for HLAP were evaluated using receiver operating characteristic(ROC)curves.Results Levels of TyG,AIP,SII,and SCr were significantly higher in moderate-severe/severe group than in mild group(P<0.05).Logistic regression analysis revealed that TyG,AIP,and SCr were independent risk factors for moderate-severe/severe HLAP(P<0.05),whereas SII was not an independent risk factor.The severity of HLAP was positively correlated with early admission levels of TyG,AIP,and SCr.ROC curve analysis demonstrated that TyG showed superior diagnostic value compared to SCr and AIP.The combined indicators(SCr+AIP and SCr+TyG)outperformed single indicators in predictive value,with SCr+TyG exhibiting the highest predictive efficacy.Conclusion Early TyG,AIP,and SCr levels can serve as effective indicators for predicting disease severity in HLAP patients,and combined detection improves predictive accuracy.
作者
姚艳文
薛涛
黄三雄
姚林华
YAO Yanwen;XUE Tao;HUANG Sanxiong;YAO Linhua(Department of Gastroenterology,Huzhou First People’s Hospital,Huzhou 313000,Zhejiang,China;Clinical Trial Center,Huzhou First People’s Hospital,Huzhou 313000,Zhejiang,China;Department of Hepatobiliary and Pancreatic Surgery,Huzhou First People’s Hospital,Huzhou 313000,Zhejiang,China)
出处
《中国现代医生》
2025年第26期1-5,共5页
China Modern Doctor
基金
浙江省基础及公益基金项目(LGF21H030001)
湖州市科技计划项目(2021GZB06)。
作者简介
通信作者:姚林华,电子信箱:yaolinhua110@163.com。
