摘要
目的 探讨血栓弹力图(TEG)参数、纤维蛋白(原)降解产物(FDP)水平对结直肠癌并发静脉血栓栓塞症的预测价值。方法 回顾性选择2019年6月至2024年6月武警河南总队医院收治的80例结直肠癌并发静脉血栓栓塞症患者作为观察组,同期住院未发生静脉血栓栓塞症的85例结直肠癌患者作为对照组。检测两组TEG参数[凝血反应时间(R值)、凝固角(α角)、最大振幅(MA)、凝血指数(CI)]、FDP水平及凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)。采用受试者操作特征(ROC)曲线分析TEG参数、FDP水平对结直肠癌并发静脉血栓栓塞症的预测价值。结果 观察组R值低于对照组,α角、CI大于对照组,MA、FDP水平高于对照组,差异有统计学意义(P<0.05)。观察组TT、PT长于对照组,APTT短于对照组,差异有统计学意义(P<0.05)。R值、α角、MA、CI、FDP水平联合检测预测结直肠癌并发静脉血栓栓塞症的曲线下面积(AUC)高于单项检测(Z_(R-联合检测)=5.405、Z_(α-联合检测)=3.867、Z_(MA-联合检测)=4.560、Z_(CI-联合检测)=3.985、Z_(FDP~联合检测)=4.997,P<0.05)。结论 TEG参数联合FDP水平检测在预测结直肠癌并发静脉血栓栓塞症方面具有较高的临床价值。
Objective To investigate the predictive value of thromboelastography(TEG)fibrin degradation product(FDP)levels for venous thromboembolism complicating colorectal cancer.Methods A retrospective study selected 80 patients with colorectal cancer complicated by venous thromboembolism who were admitted to Henan Armed Police Corps Hospital from June 2019 to June 2024 as the observation group,and 85 hospitalized patients with colorectal cancer without venous thromboembolism during the same period as the control group.TEG parameters[reaction time(R value),αangle,maximum amplitude(MA),coagulation index(CI)],FDP level,thrombin time(TT),prothrombin time(PT),and activated partial thromboplastin time(APTT)were measured in both groups.Receiver operating characteristic(ROC)curve analysis was used to evaluate the predictive value of TEG parameters and FDP level for venous thromboembolism complicating colorectal cancer.Results The observation group had a lower R value than the control group,higherαangle and CI than the control group,and higher MA and FDP level than the control group;these differences were statistically significant(P<0.05).The observation group had longer TT and PT and a shorter APTT than the control group(P<0.05).The area under the ROC curve(AUC)for combined detection of R value,αangle,MA,CI,and FDP level in predicting venous thromboembolism complicating colorectal cancer was higher than that for single-parameter detection(Z R for combined detection=5.405,Zαfor combined detection=3.867,Z MA for combined detection=4.560,Z CI for combined detection=3.985,Z FDP for combined detection=4.997;P<0.05).Conclusion Combined measurement of TEG parameters and FDP level has high clinical value in predicting venous thromboembolism complicating colorectal cancer.
作者
郭俊芳
肖华
李志婷
王诗苑
GUO Junfang;XIAO Hua;LI Zhiting;WANG Shiyuan(Department of Laboratory Medicine and Pathology,Henan Armed Police Corps Hospital,Zhengzhou Henan 450007,China;Department of Laboratory Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou Henan 450007,China;Department of Laboratory Medicine,Henan Armed Police Corps Hospital,Zhengzhou Henan 450007,China)
出处
《临床研究》
2025年第9期127-129,133,共4页
Clinical Research
作者简介
郭俊芳,女。研究方向:血栓与止血;通讯作者:肖华,副主任技师,xiaohua991212@163.com。
