摘要
目的探讨新辅助化疗与腹腔镜手术联合应用于胃肠肿瘤治疗对患者免疫功能的影响。方法选取本院2022年1月—2023年6月收治的80例胃肠肿瘤患者作为研究对象,随机分为参照组和实验组,每组40例患者,参照组患者接受传统腹腔镜手术治疗,实验组患者在接受腹腔镜手术之前先接受新辅助化疗,对比两组的治疗效果以及免疫功能的变化情况。结果参照组治疗后总有效率是65.00%,实验组是87.50%,两组相比差异有统计学意义(P<0.05);实验组在手术切除率上明显比参照组高,术中出血量、手术时间和术后胃肠恢复时间均少于参照组,且两组相比差异有统计学意义(P<0.05);治疗后CD3^(+)、CD4^(+)、CD8^(+)及NK细胞活性指标均比治疗前明显下降,实验组各项水平则明显比参照组高,证明治疗对实验组免疫功能的影响较参照组轻,两组相比差异有统计学意义(P<0.05);参照组并发症的总发生率是37.50%,实验组是10.00%,两组相比差异有统计学意义(P<0.05)。结论对胃肠肿瘤患者采取新辅助化疗与腹腔镜手术联合治疗方案疗效更明显,对患者免疫功能的影响较小,值得进行推广。
Objective To explore the effect of neoadjuvant chemotherapy combined with laparoscopic surgery on the immune function of patients with gastrointestinal tumor treatment.Methods 80 gastrointestinal tumor patients were selected as the main body of this study within the time period from January 2022 to June 2023,and were randomly assigned to two groups,namely the reference group and the experimental group,each group consisting of 40 patients.In the reference group,the patients underwent traditional laparoscopic surgery for treatment,while for the experimental group,the patients first received neoadjuvant chemotherapy before undergoing laparoscopic surgery,comparing the treatment effect and changes in immune function in the two groups.Results The total effective efficiency of the reference group after treatment was 65.00%,and the experimental group was 87.50%,the difference was statistically significant(P<0.05).The experimental group was significantly higher in surgical resection rate than the reference group.The amount of bleeding during surgery,the time of surgery and the time of recovery of gastrointestinal function after surgery were less than that of the reference group,the difference was statistically significant(P<0.05).After treatment,the activity index of CD3^(+),CD4^(+),CD8^(+)and NK cells were significantly lower than before treatment,and the levels of the experimental group were significantly higher than that of the reference group,which proved that the impact of treatment on the immune function of the experimental group was lighter than that of the reference group,the difference was statistically significant(P<0.05).The total incidence of complications in the reference group was 37.50%,10.00%in the experimental group,the difference was statistically significant(P<0.05).Conclusion The combination treatment plan for neoadjuvant chemotherapy and laparoscopic surgery for gastrointestinal tumor patients has more obvious efficacy,and has a relatively small impact on the patient's immune function,which is worthy of promotion.
作者
鞠振煜
张婉莹
JU Zhenyu;ZHANG Wanying(Baicheng Central Hospital,Baicheng,Jilin 137000)
出处
《智慧健康》
2025年第21期43-46,共4页
Smart Healthcare
关键词
新辅助化疗
腹腔镜手术
胃肠肿瘤
免疫功能
Neoadjuvant chemotherapy
Laparoscopic surgery
Gastrointestinal tumors
Immune function
作者简介
鞠振煜(1980-),男,汉族,吉林白城人,硕士,副主任医师,研究方向:胃肠肿瘤。
