摘要
目的基于表面增强拉曼光谱技术(Surface-Enhanced Raman Spectroscopy,SERS),建立一种适用于甲基苯丙胺(Methamphetamine,MA)的现场快速检测方法。方法以实验室自制的胶体银纳米颗粒(Silver Nanoparticles,AgNPs)作为SERS基底,对犯罪现场典型基质(啤酒、烟灰、塑料容器)样本中的甲基苯丙胺进行快速检测分析。结果该方法无需样本预处理,操作简便、灵敏度高、检测速度快,最低检出限可达10 ppb(信噪比S/N>3)。对缉毒实战检材进行甲基苯丙胺分析,其定性结果与色谱-质谱联用技术检测结果高度吻合。结论甲基苯丙胺常见于非法场所和犯罪活动中,本研究实现了对啤酒、烟灰、塑料容器样本中的甲基苯丙胺的快速检测分析,实战应用前景良好,对于执法部门、公共安全以及刑事侦查具有重要意义。
Objective To establish a rapid on-site detection method for methamphetamine(MA)based on surface enhanced Raman spectroscopy(SERS).Methods Laboratory-synthesized colloidal silver nanoparticles(AgNPs)were employed as SERS substrates to rapidly detect methamphetamine in typical crime scene matrices,including beer,cigarette ash,and plastic containers.Results The method requires no sample pretreatment,is simple to operate,and offers high sensitivity with fast detection speed.The limit of detection(LOD)reached 10 ppb(signal-to-noise ratio,S/N>3).The qualitative results of methamphetamine analysis from forensic case samples were highly consistent with gas chromatography-mass spectrometry(GC-MS)findings.Conclusion Methamphetamine is frequently encountered in illicit settings and criminal activities.This study achieved rapid detection of methamphetamine in complex matrices(beer,cigarette ash,and plastic containers),demonstrating good application prospects in practice and providing important value for law enforcement,public safety,and criminal investigation.
作者
廖彩云
张雅婷
杨荣极
杨柳
李国娟
刘晨曦
任闻
杨洲
Liao Caiyun;Zhang Yating;Yang Rongji;Yang Liu;Li Guojuan;Liu Chenxi;Ren Wen;Yang Zhou(National Anti-Drug Laboratory Sichuan Regional Center,Chengdu 610200,Sichuan,China;University of Electronic Science and Technology of China,Chengdu 610200,Sichuan,China)
出处
《中国法医学杂志》
2025年第4期459-462,共4页
Chinese Journal of Forensic Medicine
关键词
表面增强拉曼光谱技术
甲基苯丙胺
银纳米颗粒
快速检测
加标试验
Surface-enhanced raman spectroscopy(SERS)
Methamphetamine
Silver nanoparticles
Rapid detection
Spiked test
作者简介
廖彩云,女,工程师,硕士,主要从事毒物毒品分析研究。
