摘要
目的探究血浆β淀粉样蛋白(Aβ)与认知功能障碍的关系。方法选取西安市鄠邑区某2个自然村40岁及以上常住村民作为研究对象,通过问卷调查、体格检查和实验室检查评估一般状况和认知功能障碍危险因素;采用简易精神状态量表检查(Mini-Mental State Examination,MMSE)及成套神经心理量表评估认知功能,并将人群分为认知功能正常组、可疑认知功能障碍组、认知功能障碍组。酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)测定空腹血浆中Aβ_(1-42)、Aβ_(1-40)水平。单因素和多因素分析血浆Aβ与认知功能障碍的关系。结果1314名研究对象中,认知功能正常1180例(89.8%),可疑认知功能障碍85例(6.47%),认知功能障碍49例(3.73%)。单因素分析显示,可疑认知功能障碍组血浆Aβ_(1-42)/Aβ_(1-40)比值高于认知功能正常组(P<0.05)及认知功能障碍组(P<0.05),可疑认知功能障碍组血浆Aβ_(1-42)水平高于认知功能正常组(P<0.05)。3组间血浆Aβ_(1-40)水平差异无统计学意义。多因素Logistic回归分析校正混杂因素后(包括年龄、性别、教育程度、认知功能障碍危险因素、生活习惯),分析结果与单因素分析一致。结论可疑认知障碍患者血浆Aβ_(1-42)水平和Aβ_(1-42)/Aβ_(1-40)比值显著升高,提示血浆Aβ_(1-42)升高可能在认知障碍早期更为明显,有望作为认知功能下降的早期生物标记物。
Objective To explore the relationship between plasma amyloid-β(Aβ)and cognitive impairment.Methods A total of all villagers(aged 40 years and above)from two villages of Xi’an,China,were enrolled.A validated Chinese version of the Mini-Mental State Examination and neuropsychological battery were used to assess cognition.Levels of fasting plasma Aβ_(1-42) and Aβ_(1-40) were tested using commercial enzyme-linked immunosorbent assay(ELISA).Relationship between plasma Aβand cognitive impairment was analyzed using Logistic regression analysis.Results Of the 1314 enrolled subjects,1180(89.80%)had normal cognition,85(6.47%)had suspected cognitive impairment,and 49(3.73%)had probable cognitive impairment.Univariate analysis showed that plasma Aβ_(1-42)/Aβ_(1-40) ratio was higher in the suspected cognitive impairment group than in the probable cognitive impairment group(P<0.05)and normal cognitive group(P<0.05);plasma Aβ_(1-42) level in the suspected cognitive impairment group was higher than that in normal cognitive group(P<0.05).The level of Aβ_(1-40) did not differ between the three groups.After correcting for confounding factors(including age,gender,degree of education,cognitive impairment risk factors,habits of living)in the multivariate Logistic regression analysis,the results were consistent with those in the univariate analysis.Conclusion Levels of plasma Aβ_(1-42) and Aβ_(1-42)/Aβ_(1-40) ratio were elevated in patients with suspected cognitive impairment,indicating that elevated plasma Aβ_(1-42) and Aβ_(1-42)/Aβ_(1-40) ratio may be more pronounced in early stage of cognitive impairment.They may be early biomarkers for cognitive impairment,which can help identify and intervene the disease earlier.
作者
胡童鑫
马欢
商苏杭
高玲
党亮君
王敬谊
屈秋民
王瑾
HU Tongxin;MA Huan;SHANG Suhang;GAO Ling;DANG Liangjun;WANG Jingyi;QU Qiumin;WANG Jin(Department of Neurology,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an;Department of Encephalopathy,Huyi Hospital of Traditional Chinese Medicine,Xi’an,China)
出处
《西安交通大学学报(医学版)》
北大核心
2025年第5期804-810,共7页
Journal of Xi’an Jiaotong University(Medical Sciences)
基金
国家科技部科技创新2030-“脑科学与类脑研究”重大项目(No.2021ZD0201808)资助。
作者简介
通信作者:王瑾,副主任医师.E-mail:drwangjin@xjtufh.edu.cn;第一作者:胡童鑫;共同第一作者:马欢。
