摘要
目的观察不同穴位针刺治疗无先兆偏头痛的临床疗效及对患者血清降钙素基因相关肽(calcitonin gene-related peptide,CGRP)和5-羟色胺(5-hydroxytrptamine,5-HT)水平的影响。方法将60例无先兆偏头痛患者随机分为观察组和对照组,每组30例。对照组采用常规针刺治疗,观察组采用“头七针”针刺治疗。观察两组治疗前后和随访时视觉模拟量表(visual analog scale,VAS)评分、头痛症状评分及偏头痛-特异生活质量问卷(migraine-specific quality of life,MSQOL)评分的变化,观察两组治疗前后血清CGRP和5-HT水平,并比较两组临床疗效和不良反应发生情况。结果两组治疗后和随访时VAS评分低于治疗前(P<0.05);对照组随访时VAS评分低于治疗后(P<0.05);观察组治疗后和随访时VAS评分低于对照组(P<0.05)。两组治疗后和随访时头痛症状评分低于治疗前(P<0.05);观察组治疗后和随访时头痛症状评分低于对照组(P<0.05)。对照组随访时MSQOL评分高于治疗前(P<0.05);观察组治疗后和随访时MSQOL评分高于治疗前,随访时高于治疗后,差异有统计学意义(P<0.05);观察组治疗后和随访时MSQOL评分高于对照组(P<0.05)。治疗后,两组血清CGRP水平较治疗前降低(P<0.05),血清5-HT水平较治疗前升高(P<0.05),且观察组上述指标均优于对照组(P<0.05)。观察组治疗后总有效率为86.7%,高于对照组的63.3%(P<0.05)。观察组随访时总有效率为83.3%,高于对照组的53.3%(P<0.05)。两组均未发生不良反应。结论“头七针”针刺与常规针刺治疗无先兆偏头痛均有效。“头七针”针刺在缓解疼痛、提高生活质量方面优于常规针刺,可能与调节血清CGRP和5-HT水平有关。
Objective To observe the clinical efficacy of acupuncture at different acupoints in treating migraine without aura and the effects on the serum levels of calcitonin gene-related peptide(CGRP)and 5-hydroxytrptamine(5-HT)in the patients.Method Sixty patients with migraine without aura were randomized into an observation group or a control group,each consisting of 30 cases.The control group received ordinary acupuncture treatment,and the observation group received“Tou Qi Zhen”treatment.The two groups were observed before and after the treatment and at the follow-up for changes in the visual analog scale(VAS)score,headache symptoms score,and migraine-specific quality of life(MSQOL)score.The serum levels of CGRP and 5-HT were measured before and after the treatment.The clinical efficacy and adverse reactions were compared between the two groups.Result The VAS score was lower after the treatment and at the follow-up compared to that before the treatment in each group(P<0.05);the control group had a lower VAS score at the follow-up compared to that after the intervention(P<0.05);the observation group had a lower VAS score compared to the control group after the treatment and at the follow-up(P<0.05).The headache symptoms score dropped after the treatment and at the follow-up compared to that before the treatment in both groups(P<0.05)and was lower in the observation group than in the control group(P<0.05).The control group had a higher MSQOL score at the follow-up compared to its pre-treatment score(P<0.05);the observation group had a higher MSQOL score after the treatment and at the follow-up compared to its pre-treatment score,and the score was higher at the follow-up compared to that after the treatment,showing statistical significance(P<0.05);the observation group was higher than the control group when comparing the MSQOL score after the treatment and at the follow-up(P<0.05).After the intervention,both groups had a decrease in the serum level of CGRP(P<0.05)and an increase in the serum level of 5-HT(P<0.05),and the observation group showed superiority compared to the control group(P<0.05).After the treatment,the total effective rate was 86.7%in the observation group,higher than 63.3%in the control group(P<0.05).At the follow-up,the total effective rate was 83.3%in the observation group,higher than 53.3%in the control group(P<0.05).Neither group showed adverse reactions.Conclusion“Tou Qi Zhen”and ordinary acupuncture are effective approaches for migraine without aura.Compared to ordinary acupuncture,“Tou Qi Zhen”has advantages in releasing pain and enhancing the quality of life,and the effects are plausibly related to the regulation of serum CGRP and 5-HT levels.
作者
宰风雷
郭笑彤
冀来喜
王志福
连紫宇
宋珊
程江慧
连旭霞
ZAI Fenglei;GUO Xiaotong;JI Laixi;WANG Zhifu;LIAN Ziyu;SONG Shan;CHENG Jianghui;LIAN Xuxia(Heping Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China;Shanxi University of Chinese Medicine,Taiyuan 030024,China;Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350000,China)
出处
《上海针灸杂志》
2025年第9期1063-1069,共7页
Shanghai Journal of Acupuncture and Moxibustion
基金
山西省中医药管理局科研课题(2022ZYYC134)
山西省卫生健康委员会基层适宜性技术推广应用项目。
关键词
针刺疗法
无先兆偏头痛
头七针
降钙素基因相关肽
5-羟色胺
Acupuncture therapy
Migraine without aura
Tou Qi Zhen
Calcitonin gene-related peptide
5-hydroxytrptamine
作者简介
宰风雷(1978—),男,主任医师,Email:zaifenglei@163.com。
