摘要
目的:研究毫火针治疗白癜风的效果和免疫学机制。方法:将52例白癜风患者随机分为试验组和对照组,试验组患者接受毫火针治疗(1次/周),对照组患者外用0.1%他克莫司软膏治疗(2次/d),均连续治疗12周。治疗前后分别对两组患者皮损处行反射共聚焦显微镜(reflectance confocal microscopy,RCM)检查并抽血检测肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)水平,同时每4周进行1次白癜风面积评分指数(vitiligo area scoring index,VASI)评估,最后进行比较分析。结果:治疗前,两组患者一般情况比较,差异无统计学意义(P>0.05);治疗12周后,与对照组患者相比,试验组患者的RCM检查结果显著改善,VASI评分和TNF-α水平显著下降(均P<0.05)。结论:毫火针和0.1%他克莫司软膏治疗白癜风均有一定效果,但毫火针的疗效更显著。毫火针治疗还能有效降低患者静脉血中的TNF-α水平,可能因此而减少黑素细胞的凋亡。
Objective:To study the effects and immunological mechanisms of fine-fire needle therapy on vitiligo.Methods:Fifty-two patients with vitiligo were randomly divided into a control group and an experimental group with 26 cases each.The experimental group received fine-fire needle treatment(once a week),while the control group was treated with topical 0.1%tacrolimus ointment(twice a day),and the treatment was lasted for 12 consecutive weeks.Reflectance confocal microscopy(RCM)examinations were conducted on the skin lesions of the patients,and blood samples were collected to test the levels of tumor necrosis factor-α(TNF-α)before and after treatment.Additionally,the vitiligo area scoring index(VASI)was assessed every 4 weeks,followed by a comparative analysis.Results:The comparison of general conditions between the two groups showed no statistically significant difference before treatment(P>0.05).After 12 weeks of treatment,the RCM examination results were significantly improved and VASI scores and TNF-αlevels were significantly decreased in the experimental group than the control group(P<0.05).Conclusion:Both therapies have certain effects on the treatment of vitiligo,however,the efficacy of fine-fire needle therapy is more significant.Besides,fine-fire needle therapy can also effectively reduce the levels of TNF-αin the patients’venous blood,which may consequently decrease the apoptosis of melanocytes.
作者
赵雪琪
刘红霞
郭菲
ZHAO Xueqi;LIU Hongxia;GUO Fei(Department of Dermatology,Traditional Chinese Medical Hospital of Changji Hui Autonomous Prefecture,Changji 831100,China;Department of Dermatology,Institute of Traditional Chinese Medicine,Xinjiang Uygur Autonomous Region,Urumqi 830000,China;Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《上海医药》
2025年第8期16-19,共4页
Shanghai Medical & Pharmaceutical Journal
基金
2019年新疆维吾尔自治区创新环境建设专项(自然科学基金)联合基金项目(2019D01C175)。
关键词
肿瘤坏死因子Α
白癜风
毫火针
tumor necrosis factor-α
vitiligo
fine-fire needle
作者简介
通信作者:郭菲,副主任医师。研究方向:皮肤病的中西医结合诊疗。
