摘要
目的:观察炼脐法治疗原发性痛经(PD)气滞血瘀证的临床疗效。方法:选取2023年3—11月在甘肃医学院校内治疗的60例PD气滞血瘀证患者,按随机数字表法分为对照组和观察组各30例。对照组采用布洛芬缓释胶囊口服治疗,观察组使用炼脐法治疗。2组均治疗3个月经周期。比较2组临床疗效,治疗前后的疼痛视觉模拟评分法(VAS)评分、中医证候积分、白细胞介素-6(IL-6)、前列腺素F_(2α)(PGF_(2α))、前列腺素E_(2)(PGE_(2))、β-内啡肽(β-EP)水平。结果:治疗后,观察组总有效率93.33%(28/30),高于对照组76.67%(23/30)(P<0.05)。2组疼痛VAS评分、中医证候积分均较治疗前降低(P<0.05),观察组疼痛VAS评分、中医证候积分均低于对照组(P<0.05)。观察组血清PGE_(2)、β-EP水平均较治疗前升高(P<0.05),观察组血清PGE_(2)、β-EP水平均高于对照组(P<0.05)。2组血清PGF_(2α)、IL-6水平均较治疗前降低(P<0.05);组间血清PGF_(2α)、IL-6水平比较,差异均无统计学意义(P>0.05)。结论:炼脐法治疗PD气滞血瘀证疗效好,通过调节机体前列腺素、疼痛相关因子水平,抑制炎症反应,可缓解临床症状,减轻疼痛,且安全性好。
Objective:To observe the clinical effect of Umbilical Fumigation Method on primary dysmenorrhea(PD)with qi stagnation and blood stasis syndrome.Methods:A total of 60 cases of PD patients with qi stagnation and blood stasis syndrome treated at Gansu Medical College from March 2023 to November 2023 were selected and divided into the control group and the observation group based on the random number table method,with 30 cases in each group.The control group was given the oral administration of Ibuprofen Sustained-Release Capsules,and the observation group was treated with Umbilical Fumigation Method.Both groups were treated for three menstrual cycles.The Visual Analogue Scale(VAS)scores for pain,traditional Chinese medicine syndrome scores,and levels of interleukin-6(IL-6),prostaglandin F2α(PGF_(2α)),prostaglandin E_(2)(PGE_(2)),andβ-endorphin(β-EP)before and after treatment as well as the clinical effects were compared between the two groups.Results:After treatment,the total effective rate was 93.33%(28/30)in the observation group,higher than 76.67%(23/30)in the control group(P<0.05).VAS scores for pain and traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),with the observation group showing lower scores than the control group(P<0.05).The levels of PGE_(2) andβ-EP in serum in the observation group were increased when compared with those before treatment(P<0.05)and were higher than those in the control group(P<0.05).The levels of PGF_(2α)and IL-6 in serum in the two groups were reduced when compared with those before treatment(P<0.05),with no significant difference between the two groups(P>0.05).Conclusion:The Umbilical Fumigation Method has a good curatice effect in treating PD with qi stagnation and blood stasis syndrome.By regulating the levels of prostaglandins and pain-related factors and inhibiting inflammatory responses,it can alleviate clinical symptoms and reduce pain,with good safety.
作者
赵敏
罗芳丽
陶欢
冯彬
王利军
ZHAO Min;LUO Fangli;TAO Huan;FENG Bin;WANG Lijun(Gansu Medical College,Pingliang Gansu 744000,China;Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 610075,China)
出处
《新中医》
2025年第17期93-98,共6页
New Chinese Medicine
基金
2024年甘肃省高校教师创新基金项目(2024A-217)
甘肃医学院2022年校级科研项目(GY-2022ZK013)。
关键词
原发性痛经
气滞血瘀证
炼脐法
炎症因子
疼痛视觉模拟评分法
Primary dysmenorrhea
Qi stagnation and blood stasis syndrome
Umbilical Fumigation Method
Inflammatory factors
Visual Analogue Scale of pain
作者简介
赵敏(1986-),女,讲师,E-mail:373440042@qq.com。;通信作者:王利军(1981-),男,副教授,E-mail:wlj812140@163.com。
