摘要
胃癌发病率和死亡率均较高。化疗是胃癌的一线治疗方案,已经在胃癌治疗领域取得了显著成效。然而,由于个体差异和肿瘤异质性等,化疗药物的治疗效果在不同患者中存在差异。因此,准确评估患者对化疗药物的敏感性对于实施个体化治疗具有重要意义。胃癌类器官是预测患者对化疗药物敏感性的一个有效工具。本综述总结了胃癌类器官在化疗药物敏感性测定中的应用及相关研究进展,探讨类器官模型的优势和不足之处,并对未来研究方向提出展望,期望类器官能为胃癌治疗提供更有效的个体化治疗方案和更多的药物选择。
Gastric cancer has high incidence and mortality rate.Chemotherapy is the first-line treatment for gastric cancer and has achieved considerable success.However,due to genetic variations and tumor heterogeneity,the effectiveness of chemothrapy drugs varies among different patients.Therefore,accurate assessment of patient’s sensitivity to chemotherapy drugs is crucial for personalized treatment.Gastric cancer organoids serve as effective tools for predicting patient’s sensitivity to chemotherapy drugs.This review summarizes the applications and related research progress of gastric cancer organoids in determining chemotherapy drug sensitivity,discusses the strengths and limitations of organoid models,and proposes outlooks for future research directions,hoping that organoids can provide more effective personalized treatment options and a greater range of drug choices for gastric cancer treatment.
作者
杨欣怡
尹毅锐
黄哲昆
叶岩荣
沈赟
王路敏
YANG Xinyi;YIN Yirui;HUANG Zhekun;YE Yanrong;SHEN Yun;WANG Lumin(Department of Pharmacy,Zhongshan Hospital(Xiamen Branch),Fudan University,Xiamen 360105,Fujian,China;Department of Pharmacy,Zhangzhou Municipal Hospital of Fujian Province,Zhangzhou 363000,Fujian,China;Department of General Surgery,Zhongshan Hospital(Xiamen Branch),Fudan University,Xiamen 360105,Fujian,China;Department of Pharmacy,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《中国临床医学》
2025年第4期685-691,共7页
Chinese Journal of Clinical Medicine
基金
福建省卫生健康科技计划项目(2020QN01010036)。
关键词
胃癌
类器官
化疗药物
敏感性测定
个体化治疗
gastric cancer
organoid
chemotherapy drug
sensitivity testing
personalized therapy
作者简介
杨欣怡,2024届厦门医学院药学系本科毕业生.E-mail:2311075903@qq.com;通信作者:王路敏.Tel:0592-3568368,E-mail:wang.lumin@zsxmhospital.com。
