摘要
肠道微生物群落对宿主免疫系统的发育调控与稳态维持有着决定性影响,借助模式识别受体(PRRs)、代谢产物(如短链脂肪酸/SCFAs)及抗原呈递细胞(APCs)激活免疫通路,可调控T细胞分化过程,维持肠道屏障结构稳定,并抑制系统性炎症反应。文章主要研究菌群介导的免疫调控路径,揭示微生物—免疫互作的核心机制,旨在为精准医学、益生菌治疗及肠道微生态干预提供理论依据。
The gut microbiota plays a decisive role in the development,regulation,and homeostasis of the host immune system.Through pattern recognition receptors(PRRs),metabolic products(such as short-chain fatty acids,SCFAs),and antigen-presenting cells(APCs),the microbiota activates immune pathways.This mechanism can modulate T-cell differentiation,maintain intestinal barrier integrity,and suppress systemic inflammatory responses.The article focuses on microbiota-mediated immune regulatory pathways,elucidates the core mechanisms of microbe-immune interactions,aiming to provide theoretical insights for precision medicine,probiotic therapy,and gut microbiota interventions.
作者
韩迪
HAN Di(Zhengzhou Health Vocational College,Zhengzhou 450100,China)
出处
《工业微生物》
2025年第4期89-91,共3页
Industrial Microbiology
作者简介
韩迪(1985.11-),女,汉族,河南商丘人,助教,硕士,研究方向:基础医学。
