摘要
山莨菪碱(654-2)对二氧化硫吸入所致大鼠急性气管炎,角叉菜胶所致大鼠脚爪水肿,油酸所致大鼠急性肺损伤及博莱霉素A5所致肺纤维化均有保护作用。阻断组胺作用及抑制溶酶体酶的释放,可能是654-2抗炎症作用的部分环节。
Effects of anisodamine(654-2)on inflammatory reaction were investigated.Results showed that anisodamine could inhibit SO2-induced acute bronchitis in rats,carrageenen-induced rat paw edema,oleic acid-induced rat lung injury,and bleomycin A5-induced mouse lung fibrosis.It is suggested that inhibition of histamine pharmacological effect and lysosomal enzyme release may be responsible for antiinflammatory effect of anisodamine.
作者
陈祥银
严仪昭
曾卫东
西品香
Chen Xiangyin;Yan Yizhao;Zeng Weidong;Xi Pinxiang(Institute of Basic Medical Sciences,Academiae Medicinae Sinicae,Beijing)
出处
《中国医学科学院学报》
1987年第1期13-17,共5页
Acta Academiae Medicinae Sinicae
关键词
山莨菪碱
炎症
组胺
溶酶体
anisodamine
inflammation
histamine
lysosome
作者简介
曾卫东,江西医院进修医师。
