摘要
目的:分析晚期不可切除胰腺癌预后的影响因素。方法:选取郑州大学第一附属医院2018年1月至2023年2月收治的310例晚期不可切除胰腺癌患者,均予以化疗和定期随访。将肿瘤性死亡作为观察终点,采用Cox回归分析预后影响因素。结果:未/低分化、降钙素原(PCT)、中性粒细胞与淋巴细胞比值(NLR)、癌胚抗原(CEA)均是不可切除胰腺癌生存的危险因素,HR(95%CI)分别为1.356(1.124~1.878)、2.273(1.354~2.965)、1.397(1.149~2.015)、1.635(1.286~2.973)。结论:未/低分化、PCT、NLR、CEA是晚期不可切除胰腺癌生存预后的危险因素。
To analyze the influencing factors for prognosis of advanced unresectable pancreatic cancer.Methods:A total of 310 patients with advanced unresectable pancreatic cancer admitted to the First Affiliated Hospital of Zhengzhou University from January 2018 to February 2023 were selected,and all received chemotherapy and regular following-up.Tumor death was taken as the observation endpoint,and the influencing factors was analyzed using Cox regression.Results:Undifferentiation and poorly differentiation,procalcitonin(PCT),neutrophil to lymphocyte ratio(NLR)and carcinoembryonic antigen(CEA)were risk factors of survival,and HR(95%CI)was 1.356(1.124-1.878),2.273(1.354-2.965),1.397(1.149-2.015),1.635(1.286-2.973),respectively.Conclusion:Undifferentiation and poorly differentiation,PCT,NLR,and CEA are risk factors for survival of advanced unresectable pancreatic cancer.
作者
张国坤
秦文杰
赵永福
ZHANG Guokun;QIN Wenjie;ZHAO Yongfu(Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)
出处
《郑州大学学报(医学版)》
北大核心
2025年第5期697-700,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
胰腺癌
预后影响因素
不可切除
pancreatic cancer
prognosis influence factor
unresection
作者简介
通信作者:赵永福,男,1936年9月生,博士,主任医师,研究方向:肝胆胰外科。
