摘要
目的观察消渴方联合达格列净治疗气阴两虚型2型糖尿病的疗效。方法选取商丘仁和中医院2022年10月至2024年5月收治的60例气阴两虚型2型糖尿病患者,根据随机数字表法分为对照组与观察组,各30例。对照组予达格列净片治疗,观察组予达格列净片联合消渴方治疗。以3个月为治疗观察终点,比较两组疗效、中医候症积分、胰岛功能[空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)]、炎症指标[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]及不良反应发生情况。结果观察组治疗总有效率[93.33%(28/30)]高于对照组[66.67%(20/30)],差异有统计学意义(P<0.05);治疗3个月,观察组中医证候积分和FINS、HOMA-IR、CRP、TNF-α水平分别为(10.23±3.15)分、(14.27±2.87)μIU/mL、(1.14±0.31)、(2.39±0.74)mg/L、(6.46±1.62)pg/mL,均低于对照组的(14.13±3.47)分、(17.40±3.24)μIU/mL、(2.73±0.26)、(4.24±0.21)mg/L、(9.71±1.28)pg/mL;观察组HOMA-β水平[(66.23±8.15)%]高于对照组[(58.13±7.46)%],差异有统计学意义(P<0.001);观察组不良反应发生率(6.67%)与对照组(3.33%)无统计学差异(P>0.05)。结论消渴方联合达格列净治疗气阴两虚型2型糖尿病的疗效显著,能显著改善患者胰岛功能、减轻炎症,且安全性好。
Objective To observe the efficacy of Xiaoke formula combined with dapagliflozin in the treatment of type 2 diabetes mellitus(T2DM)with Qi-Yin deficiency.Methods Sixty patients with T2DM and Qi-Yin deficiency treated at Shangqiu Renhe Hospital of Traditional Chinese Medicine from October 2022 to May 2024 were selected and randomly divided into a control group and an observation group,with 30 cases in each group.The control group received dapagliflozin tablets,while the observation group received dapagliflozin tablets combined with Xiaoke formula.The treatment endpoint was set at 3 months.The efficacy,traditional Chinese medicine(TCM)symptom scores,pancreatic islet function[fasting insulin(FINS),homeostatic model assessment of insulin resistance(HOMA-IR),homeostatic model assessment of β-cell function(HOMA-β)],inflammatory markers[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],and adverse reactions were compared between the two groups.Results The observation group demonstrated significantly higher total response rate(93.33%)compared to the control group(66.67%)(P<0.05).After 3 months of treatment,the observation group exhibited significantly lower levels of TCM syndrome score[(10.23±3.15)points],FINS[(14.27±2.87)μIU/mL],HOMA-IR(1.14±0.31),CRP[(2.39±0.74)mg/L],and TNF-α[(6.46±1.62)pg/mL]compared to the control group[(14.13±3.47)points,(17.40±3.24)μIU/mL,(2.73±0.26),(4.24±0.21)mg/L,(9.71±1.28)pg/mL,respectively],whereas HOMA-β level[(66.23±8.15)%] was significantly higher than that in the control group[(58.13±7.46)%],with statistically significant differences(P<0.001).There was no statistically significant difference in the incidence of adverse reactions between the observation group(6.67%)and the control group(3.33%)(P>0.05).Conclusion Xiaoke formula combined with dapagliflozin is effective in the treatment of T2DM with Qi-Yin deficiency,significantly improving pancreatic islet function,reducing inflammation,and demonstrating good safety.
作者
杨磊
王丽
郑中伟
YANG Lei;WANG Li;ZHENG Zhongwei(Department of Traditional Chinese Medicine,Shangqiu Renhe Hospital of Traditional Chinese Medicine,Shangqiu Henan 476000,China)
出处
《天津药学》
2025年第8期950-954,959,共6页
Tianjin Pharmacy
关键词
2型糖尿病
气阴两虚
达格列净
消渴方
胰岛功能
炎症
Type 2 diabetes mllitus
Qi-Yin deficiency
Dapagliflozin
Xiaoke formula
Pancreatic islet function
Inflammation
