摘要
目的:基于数据挖掘探讨中医药治疗化疗诱导的周围神经病变(chemotherapy-induced peripheral neuropathy, CIPN)的用药规律。方法:收集2014—2023年中国知网收录有关中药治疗CIPN的文献,采用Excel录入处方信息,建立数据库,运用中医传承计算平台(V3.5)及SPSS Statistics 27.0统计用药频次、功效分类、性味归经,并对高频药物进行聚类分析及因子分析。结果:纳入的105个内服中药方剂中,使用频次位于前10位的中药分别是黄芪、当归、甘草、桂枝、白芍、大枣、川芎、生姜、鸡血藤、白术;药物功效以补虚类为主,其次为活血化瘀类和解表类;药性以温性为主,药味以甘、苦为主,归经以脾经、肝经为主。79个外用方剂中,用药频次位于前10位的中药分别是桂枝、红花、川芎、黄芪、当归、鸡血藤、威灵仙、赤芍、艾叶、白芍,药物功效为活血化瘀类为主;其次为补虚类和祛风湿类;药性以温性为主,药味以辛为主,归经以肝经、心经为主。对24味内服中药的高频药物进行系统聚类,可聚类为4类;对21味外用中药的高频药物进行系统聚类,可聚类为3类。结论:CIPN的治疗应以益气补虚、活血化瘀为基本原则,内服以益气养血为主,气血充盈方可温经通痹;外用以活血祛瘀为主,辅祛风散寒除湿以通络。
Objective:To explore the medication patterns of Chinese medicinals for chemotherapy-induced peripheral neuropathy(CIPN)using data mining methods.Methods:Literature on for treating CIPN from 2014 to 2023 was retrieved from the CNKI database.Relevant literature on the treatment of CIPN with Chinese medicinals from 2014 to 2023 in the China National Knowledge Infrastructure(CNKI)Academic Journal Database was collected.Formula information was entered into Excel to establish a database.The TCM Inheritance Computing Platform(V3.5)and SPSS Statistics 27.0 were used to statistically analyze the frequency of drug use,efficacy classification,properties and meridians.Cluster analysis and factor analysis were conducted on the high-frequency drugs.Results:Among the 105 internal formulas included,the top 10 most frequently used drugs were Huangqi(Radix Scutellariae),Danggui(Radix Angelicae Sinensis),Gancao(Radix Glycyrrhizae),Guizhi(Ramulus Cinnamomi),Baishao(Radix Paeoniae Alba),Dazao(Fructus Jujubae),Chuanxiong(Rhizoma Chuanxiong),Shengjiang(Rhizoma Zingiveris Recens),Jixueteng(Caulis Spatholobi),and Baizhu(Rhizoma Atractylodis Macrocephalae).The main efficacy was tonifying deficiency,followed by promoting blood circulation and removing blood stasis and relieving the exterior.The main properties were warm,and the main flavors were sweet and bitter.The meridian tropism mainly involves the spleen and liver meridians.Among the 79 external formulas,the top 10 most frequently used Chinese medicinals were Guizhi(Ramulus Cinnamomi),Honghua(Flos Carthami),Chuanxiong(Rhizoma Chuanxiong),Huangqi(Radix Scutellariae),Danggui(Radix Angelicae Sinensis),Jixueteng(Caulis Spatholobi),Weilingxian(Radix et Rhizoma Clematidis),Chishao(Radix Paeoniae Rubra),Aiye(Folium Artemisiae Argyi),and Baishao(Radix Paeoniae Alba).The main efficacy was promoting blood circulation and removing blood stasis,followed by tonifying deficiency and dispelling wind and dampness.The main properties were warm,and the main flavor was pungent.The meridian tropism mainly involves the liver and heart meridians.According to systematic cluster analysis,24 high-frequency internal drugs could be classified into 4 categories.According to systematic cluster analysis,21 high-frequency external drugs could be classified into 3 categories.Conclusion:CIPN treatment should prioritize tonifying qi,resolving deficiency and activating blood to resolve stasis.Internal treatment should focus on tonifying qi and nourishing blood,and only when qi and blood are abundant can the meridians be warmed and the obstruction relieved.External treatment should focus on promoting blood circulation and removing blood stasis,supplemented by dispelling wind,dampness and cold to unblock the meridians.
作者
丁晶晶
谷雨
DING Jingjing;GU Yu(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China,210029;Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China,210023)
出处
《河南中医》
2025年第9期1405-1411,共7页
Henan Traditional Chinese Medicine
基金
全国第七批老中医药专家学术经验继承工作项目{国中医药人教函[2022]76号}。
关键词
化疗诱导的周围神经病变
数据挖掘
用药规律
聚类分析
中医药
chemotherapy-induced peripheral neuropathy(CIPN)
data mining
medication patterns
cluster analysis
TCM
作者简介
丁晶晶(1998-),女,安徽合肥人,硕士研究生。;通信作者:谷雨,E-mail:guyugg@njucm.edu.cn。
