摘要
目的观察酮咯酸氨丁三醇联合罂粟碱治疗急性肾绞痛的临床效果,为临床提供参考。方法选取2021年6月至2024年12月南阳医学高等专科学校第一附属医院收治的95例急性肾绞痛患者作为研究对象,按照随机数字表法分为对照组(47例)和观察组(48例)。对照组采用酮咯酸氨丁三醇治疗,观察组采用酮咯酸氨丁三醇联合盐酸罂粟碱治疗。评估两组患者的临床疗效,比较两组患者中显效和有效患者的治疗起效时间和疼痛完全缓解时间,比较两组患者白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)表达水平,并分析不良反应的发生情况。结果两组治疗有效率比较,差异无统计学意义(P>0.05),两组患者显效、有效、无效人数比例分布情况比较,差异具有统计学意义(P<0.05)。观察组治疗开始起效时间和疼痛完全缓解均明显短于对照组患者,差异有统计学意义(P<0.05)。治疗后,两组患者血清IL-1β、IL-6和TNF-α的平均表达水平明显降低,且组间对比观察组患者血清IL-1β、IL-6和TNF-α平均表达水平均更低,差异有统计学意义(P<0.05)。治疗期间两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论临床治疗急性肾绞痛选用酮咯酸氨丁三醇联合罂粟碱的镇痛效果较优,可缩短治疗起效时间,改善炎症反应,且安全性良好。
Objective To observe the clinical effects of ketorolac tromethamine combined with papaverine in the treatment of acute renal colic,providing a reference for clinical practice.Methods Ninety-five patients with acute renal colic,admitted to The First Affiliated Hospital of Nanyang Medical College from June 2021 to December 2024,were selected as the study subjects.They were randomly divided into a control group(47 cases)and an observation group(48 cases)based on a random number table method.The control group received ketorolac tromethamine treatment,while the observation group received ketorolac tromethamine combined with papaverine hydrochloride treatment.The clinical efficacy of both groups was evaluated by comparing the onset time and complete pain relief time among patients with significant and effective outcomes,as well as comparing serum levels of interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α).The incidence of adverse reactions was also analyzed.Results There was no statistically significant difference in the overall treatment efficacy rates between the two groups(P>0.05).However,the proportion distribution of patients achieving significant,effective,and ineffective outcomes differed significantly between the groups(P<0.05).The observation group showed significantly shorter onset time and complete pain relief compared to the control group,with statistical significance(P<0.05).Post-treatment,the mean serum expression levels of IL-1β,IL-6,and TNF-αwere significantly reduced in both groups,with even lower levels observed in the observation group,showing statistical significance(P<0.05).The incidence of adverse reactions during the treatment period showed no statistically significant difference between the groups(P>0.05).Conclusion The combination of ketorolac tromethamine and papaverine exhibits superior analgesic effects in the clinical treatment of acute renal colic,effectively shortening the onset time,improving inflammatory responses,and demonstrating good safety.
作者
苏方欣
SU Fangxin(Emergency Department,The First Affiliated Hospital of Nanyang Medical College,Nanyang Henan 473000,China)
出处
《临床研究》
2025年第8期56-59,共4页
Clinical Research
关键词
酮咯酸氨丁三醇
罂粟碱
急性肾绞痛
临床疗效
炎症
Ketorolac Tromethamine
Papaverine
Acute Renal Colic
Clinical Efficacy
Inflammation
作者简介
苏方欣,女。研究方向:急诊急救。
