摘要
目的观察鼠神经生长因子(NGF)辅助治疗突发性耳聋的临床效果。方法本研究为前瞻性研究,研究对象为郑州大学第一附属医院2022年1月至2023年6月收治的101例突发性耳聋患者,应用电脑随机分组法将其分别列为常规组(50例)和NGF组(51例),常规组予以常规治疗,NGF组在常规组治疗基础上联合应用NGF治疗,比较两组患者的凝血功能、耳内微循环、炎症指标及听力水平。结果在不同治疗方案下,NGF组的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)分别为(26.35±5.25)s、(16.42±3.27)s,均长于常规组(23.39±5.36)s、(14.28±3.22)s,纤维蛋白原(FIB)(3.23±0.16)g/L低于常规组(4.15±0.41)g/L(t=2.804、3.313、14.910;P<0.05);NGF组的耳内血管血浆黏度、高切黏度、低切黏度分别为(1.32±0.36)mPa·s、(3.66±0.45)mPa·s、(8.35±1.21)mPa·s,均低于常规组[(2.11±0.46)mPa·s、(4.35±1.72)mPa·s、(10.44±2.38)mPa·s](t=9.622、2.770、4.265;P<0.05);NGF组的超敏C反应蛋白(hs-CRP)、白细胞介素-10(IL-10)、高迁移率蛋白1(HMGB1)分别为(8.33±1.28)mg/L、(8.25±1.46)ng/L、(1.45±0.37)mg/L,均低于常规组[(10.29±2.28)mg/L、(10.46±2.37)ng/L、(2.15±0.72)mg/L](t=5.341、5.655、6.163;P<0.05);NGF组0.25 kHz、0.50 kHz、1.00 kHz下的听力阈值分别为(30.31±5.28)dB、(25.42±5.36)dB、(20.49±5.33)dB,均低于常规组[(33.28±5.36)dB、(28.42±5.41)dB、(23.28±5.36)dB](t=2.805、2.799、2.623;P<0.05)。结论NGF辅助治疗突发性耳聋能改善患者的凝血功能及耳内微循环,可有效减轻炎症反应并促进听力水平恢复。
【Objective】To observe the clinical efficacy of nerve growth factor(NGF)assisted treatment for sudden deafness.【Methods】This prospective study included 101 patients with sudden deafness admitted to the First Affiliated Hospital of Zhengzhou University from January 2022 to June 2023.They were randomly divided into a conventional group(50 cases)and an NGF group(51 cases)using computer randomization.The conventional group received conventional treatment,while the NGF group received conventional treatment combined with NGF.Coagulation function,inner ear microcirculation,inflammatory indicators,and hearing levels were compared between the two groups.【Results】Under different treatment regimens,the activated partial thromboplastin time(APTT)and prothrombin time(PT)of the NGF group were 26.35±5.25 s and 16.42±3.27 s,respectively,higher than those in the conventional group(23.39±5.36 s and 14.28±3.22 s),while fibrinogen(FIB)was 3.23±0.16 g/L,lower than 4.15±0.41 g/L in the conventional group(t=2.804,3.313,14.910;P<0.05).The plasma viscosity,high shear viscosity,and low shear viscosity of inner ear blood vessels in the NGF group were 1.32±0.36 mPa·s,3.66±0.45 mPa·s,and 8.35±1.21 mPa·s,respectively,lower than those in the conventional group(2.11±0.46 mPa·s,4.35±1.72 mPa·s,10.44±2.38 mPa·s)(t=9.622,2.770,4.265;P<0.05).The levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-10(IL-10),and high mobility group box 1 protein(HMGB1)in the NGF group were 8.33±1.28 mg/L,8.25±1.46 ng/L,and 1.45±0.37 mg/L,respectively,lower than those in the conventional group(10.29±2.28 mg/L,10.46±2.37 ng/L,and 2.15±0.72 mg/L)(t=5.341,5.655,6.163;P<0.05).The hearing thresholds at 0.25 kHz,0.50 kHz,and 1.00 kHz in the NGF group were 30.31±5.28 dB,25.42±5.36 dB,and 20.49±5.33 dB,respectively,lower than those in the conventional group(33.28±5.36 dB,28.42±5.41 dB,and 23.28±5.36 dB)(t=2.805,2.799,2.623;P<0.05).【Conclusion】Adjuvant therapy with NGF for sudden deafness can improve coagulation function and inner ear microcirculation,effectively reduce inflammatory reactions,and promote hearing recovery in patients.
作者
胡洁
朱丽丽
HU Jie;ZHU Lii(Department of Otology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China)
出处
《中国医学工程》
2025年第8期37-41,共5页
China Medical Engineering
基金
河南省医学科技攻关项目(LHGJ202101216)。
关键词
突发性耳聋
鼠神经生长因子
耳内微循环
听力水平
Sudden deafness
Mouse nerve growth factor
inner ear microcirculation
hearing level
